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David A Estell, James A Wells: Modified enzymes and methods for making same. Genencor, James G Passe, Max D Hensley, July 26, 1988: US04760025 (251 worldwide citation)

A cloned subtilisin gene has been modified at specific sites to cause amino acid substitutions at certain spots in the enzyme. The modified enzyme, preferably produced by Bacillus, is useful in combination with detergents.


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Norbert W Bischofberger, Mark D Matteucci: Nucleic acid intercalating agents. Genentech, Daryl B Winter, Max D Hensley, December 29, 1992: US05175273 (225 worldwide citation)

Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings are provided. These polycyclic nucleosides are incorporated into oligonucleotides and hybridized to complementary nucleic acid. Fluorescence spectroscopy and thermal denaturation profiles provided evidence that th ...


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Mark Matteucci, Robert J Jones, Kuei Ying Lin: Pyrimidine derivatives. Gilead Sciences, Max D Hensley, December 21, 1999: US06005096 (210 worldwide citation)

A compound having the structure ##STR1## wherein R.sup.1 is H or a linker group; R.sup.24 is independently halo or C.sub.1 -C.sub.2 haloalkyl;


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Mark D Matteucci, Robert J Jones: Pyrimidine derivatives for labeled binding partners. Gilead Sciences, Max D Hensley, June 9, 1998: US05763588 (203 worldwide citation)

Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) ##STR1## wherein R.sup.1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1;


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Thomas J Dull, Heimo Riedel, Axel Ullrich: Novel receptors for efficient determination of ligands and their antagonists or agonists. Genentech, Max D Hensley, August 22, 1989: US04859609 (128 worldwide citation)

Hybrid receptors are provided that comprise (a) the ligand binding domain of a predetermined receptor and (b) a heterologous reporter polypeptide. The hybrid receptors are useful for convenient and large scale assay of biologically active ligands or their antagonists or agonists.


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Mary Ollidene Weaver, Edward B Bagley, George F Fanta, William M Doane: Method of reducing water content of emulsions, suspensions, and dispersions with highly absorbent starch-containing polymeric compositions. The United States of America represented by the Secretary of Agriculture, M Howard Silverstein, Max D Hensley, David G McConnell, January 27, 1976: US03935099 (116 worldwide citation)

Starch-containing polymer compositions are prepared which absorb amounts of water equaling up to more than 1000 times their own weight. The compositions find many applications including their incorporation into products such as disposable diapers, surgical pads and sheets, and paper towels.


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Antonin Holy, Erik Desire Alice De Clercq: N.sup.6 - substituted nucleotide analagues and their use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, November 2, 1999: US05977061 (103 worldwide citation)

Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivira ...


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John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (97 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


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Cornelia M Gorman: Transient expression system for producing recombinant protein. Genentech, Max D Hensley, Robert H Benson, June 18, 1991: US05024939 (94 worldwide citation)

A method is described for transient production of a desired heterologous protein comprising: transfecting a eukaryotic host cell with a vector producing a trans-activating protein; transfecting the eukaryotic host cell with an expression vector comprising a stabilizing sequence downstream of a promo ...



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