1
Hendricus R J M Hoogenboom, Michael Baier, Laurent S A T Jespers, Gregory P Winter: Production of chimeric antibodies - a combinatorial approach. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 15, 1996: US05565332 (738 worldwide citation)

Methods are disclosed which may be used for the production of antibodies, or antibody fragments, which have the same binding specificity as a parent antibody but which have increased human characteristics. Humanized antibodies may be obtained by chain shuffling, perhaps using phage display technolog ...


2
William L Thomas, Daozheng Lu: Audience measurement system utilizing ancillary codes and passive signatures. A C Nielsen Company, Marshall O Toole Gerstein Murray & Borun, January 2, 1996: US05481294 (665 worldwide citation)

An audience measurement system collects data representative of tuned programs rather than of tuned channels, and includes (i) a household metering apparatus which records ancillary codes or extracts program signatures from the programs if no ancillary codes are found therein, (ii) a reference appara ...


3
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 19, 1999: US05969108 (506 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


4
Kevin Stuart Johnson, Gregory Paul Winter, Andrew David Griffiths, Andrew John Hammond Smith, Peter Michael Waterhouse: Methods for producing members of specific binding pairs. Cambridge Antibody Technology, Medical Research Council, Marshall O Toole Gerstein Murray & Borun, March 31, 1998: US05733743 (490 worldwide citation)

Methods, recombinant host cells and kits are disclosed for the production of members of specific binding pairs (sbp), e.g. antibodies, using display on the surface of secreted replicable genetic display packages (rgdps), e.g. filamentous phage. To produce a library of great diversity, recombination ...


5
Radoje T Drmanac, Radomir B Crkvenjakov: Method of sequencing by hybridization of oligonucleotide probes. Hyseq, Marshall O Toole Gerstein Murray & Borun, June 11, 1996: US05525464 (368 worldwide citation)

The conditions under which oligonucleotide probes hybridize preferentially with entirely complementary and homologous nucleic acid targets are described. Using these hybridization conditions, overlapping oligonucleotide probes associate with a target nucleic acid. Following washes, positive hybridiz ...


6
Yanhong Li: Hypertext document retrieval system and method. IDD Enterprises, Marshall O Toole Gerstein Murray & Borun, July 6, 1999: US05920859 (365 worldwide citation)

A search engine for retrieving documents pertinent to a query indexes documents in accordance with hyperlinks pointing to those documents. The indexer traverses the hypertext database and finds hypertext information including the address of the document the hyperlinks point to and the anchor text of ...


7
Seyed M H Mehdian: Apparatus for use in the treatment of spinal disorders. Marshall O Toole Gerstein Murray Borun, June 8, 1993: US05217497 (333 worldwide citation)

An implant (10) for use in fixing one segment of a spinal column to another segment thereof by means of at least one rod member, comprises a screw member (11) for insertion in the pedicle of a segment of a spinal column and having an enlarged diameter head (13) with an open ended transverse slot (16 ...


8
Daozheng Lu, Ceril T Shagrin, William L Thomas, Morris Lee, Bruce Bernard, Jia Zhang: Audience measurement system and method. Nielsen Media Research, Marshall O Toole Gerstein Murray & Borun, June 23, 1998: US05771307 (297 worldwide citation)

In a passive identification apparatus for identifying a predetermined individual member of a television viewing audience in a monitored viewing area, a video image of a monitored viewing area is captured. A template matching score is provided for an object in the video image. A Eigenface recognition ...


9
Jean P DeJean, Daozheng Lu, Robert Weissman: Spread spectrum digital data transmission over TV video. A C Nielsen Company, Marshall O Toole Gerstein Murray & Borun, September 7, 1993: US05243423 (295 worldwide citation)

A co-channel communication system allows transmission of one or more data signals in an active or visible portion of a video raster in a manner that is imperceptible to a viewer. More particularly, the data signal is transmitted over a preselected active video lines of a video raster. In order to re ...


10
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, March 23, 1999: US05885793 (291 worldwide citation)

Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous ...