11
Choung U Kim, Matthew A Williams: Aromatic compounds. Gilead Sciences, Mark L Bosse, April 30, 1996: US05512596 (31 worldwide citation)

A composition comprising a compound of the formula: ##STR1## wherein: X is H or OH;


12
Muzammil M Mansuri, John C Martin, Thomas W Hudyma, Joanne J Bronson, Louis M Ferrara: Phosphonomethoxy carbocyclic nucleosides and nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Mark L Bosse, April 28, 1998: US05744600 (28 worldwide citation)

A compound of the Formula I or Formula II ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, ...


13
James M Chen, Xiaowu Chen, Choung U Kim, William A Lee, Christopher P Lee, Peter H Nelson, James D Tario, Lianhong Xu: Non nucleoside reverse transcriptase inhibitors. Gilead Sciences, Mark L Bosse, December 9, 2008: US07462608 (25 worldwide citation)

Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the dete ...


14
Evan M Hersch, Eskild A Petersen, Richard T Proffitt, Kevin R Bracken, Su Ming Chiang: Antibiotic formulation and use for bacterial infections. Gilead Sciences, Mark L Bosse, April 24, 2001: US06221388 (23 worldwide citation)

A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is also provided. A method is also provided for t ...


15
Edwin F Ullman: Methods for determining peroxidately active substances. Syntex, Shelley G Precivale, Mark L Bosse, August 29, 1995: US05445944 (21 worldwide citation)

Methods and compositions are disclosed for determining a peroxidatively active substance (PAS). The methods comprise the step of detecting a fluorescent signal produced upon cleavage of a compound of the formula F-L-Q, wherein F is a fluorescer capable of producing the signal, Q is a quencher capabl ...


16
Norbert W Bischofberger, Choung U Kim, Steven H Krawczyk, Lawrence R McGee, Michael J Postich, Wenjin Yang: Thiepane compounds. Gilead Sciences, Mark L Bosse, March 7, 2000: US06034118 (21 worldwide citation)

Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detectio ...


17
Edwin F Ullman: Methods for determining peroxidatively active substances. Syntex, Shelley G Precivale, Mark L Bosse, July 26, 1994: US05332662 (20 worldwide citation)

Methods and compositions are disclosed for determining a peroxidatively active substance (PAS). The methods comprise the step of detecting a fluorescent signal produced upon cleavage of a compound of the formula F-L-Q, wherein F is a fluorester capable of producing the signal, Q is a quencher capabl ...


18
Norbert W Bischofberger, Choung U Kim, Willard Lew, Hongtao Liu, Matthew A Williams: Carbocyclic compounds. Gilead Sciences, Mark L Bosse, June 9, 1998: US05763483 (17 worldwide citation)

Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of ...


19
Edwin F Ullman, Thomas C Goodman, Paul D Stull: Method for detection of specific nucleic acid sequences. Syntex, Theodore J Leitereg, Janet K Kaku, Mark L Bosse, May 14, 1996: US05516641 (17 worldwide citation)

A kit is disclosed for a method for detecting the presence of a target polynucleotide sequence. The kit comprises a first polynucleotide sequence and a second polynucleotide sequence complementary to non-contiguous portions of a target polynucleotide sequence, which first and second sequences are co ...


20
Norbert W Bischofberger, Choung U Kim, Willard Lew, Hongtao Liu, Matthew A Williams: Compounds and methods for synthesis and therapy. Gilead Sciences, Mark L Bosse, September 14, 1999: US05952375 (15 worldwide citation)

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting ...