1
Eric R Diebold, Richard J Kordal, Nigel A Surridge, Christopher D Wilsey: Electrochemical sensor. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Marilyn L Amick, August 1, 1995: US05437999 (641 worldwide citation)

A method for fabricating high-resolution, biocompatible electrodes is disclosed, allowing production of an electrochemical sensor which is capable of precise analyte concentration determination on a very small sample size. Electrically conducting material is affixed to a first insulating substrate. ...


2
Klaus H Pollmann, Martin T Gerber: Enzyme electrode system. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Marilyn L Amick, February 22, 1994: US05288636 (559 worldwide citation)

A biosensor that includes working and counter electrodes of substantially the same size and made of the same electrically conducting material. A reagent is contained in a reagent well in the biosensor. The reagent includes a redox mediator, an enzyme, and a buffer, and covers substantially equal sur ...


3
P Douglas Walling, Joseph E Bateson, Lance S Kuhn, M Luann Ochs, Kent M Kost, Martin T Gerber, Klaus H Pollmann, Chi Neng A Han: Assay method with enzyme electrode system. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Marilyn L Amick, April 16, 1996: US05508171 (504 worldwide citation)

A new electrochemical biosensor and method of its use. The electrochemical biosensor has a pair of electrodes consisting of a working electrode and a counter electrode made of the same electrically conducting materials. The counter electrode may be the same size or smaller than the working electrode ...


4
Zhi D Deng, Gerald F Sigler, Nigel A Surridge, Christopher D Wilsey, Robert J McEnroe, Walter W Jernigan, Rebecca W Muddiman: Osmium-containing redox mediator. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Marilyn L Amick, December 31, 1996: US05589326 (297 worldwide citation)

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solu ...


5
Lance S Kuhn, Mary L Ochs, Gilbert C Morris: Biosensor and method for hematocrit determination. Boehringer Mannheim Corporation, D Michael Young, Max J Kenemore, Marilyn L Amick, January 31, 1995: US05385846 (173 worldwide citation)

A biosensor and method for determining the hematocrit level of a whole blood sample using electrochemistry. The biosensor includes working and counter electrodes. A porous membrane is impregnated with an electroactive compound and is spatially displaced from the surface of the electrodes. When a who ...


6
Francis E Dwulet, Marilyn E Smith: Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease. Boehringer Mannheim Corporation, Brent A Harris, D Michael Young, Marilyn L Amick, November 3, 1998: US05830741 (30 worldwide citation)

An enzyme composition for dissociating tissues is disclosed. The composition comprises purified collagenase I and collagenase II from Clostridium histolyticum in a mass ratio of about 0.3 to 0.6 and a neutral protease such that the ratio of total FITC casein units of activity to Wunsch units of acti ...


7
Bela Molnar, Rainer Schäfer, Winfried Albert: Automated, microscope-assisted examination process of tissue or bodily fluid samples. Roche Diagnostics, Marilyn L Amick, Roche Diagnostics Corporation, June 12, 2001: US06246785 (26 worldwide citation)

Method for the automated, microscope-aided examination of tissue samples or samples of body fluids with the aid of neural networks. In a first method of examination the sample is firstly classified according to its type and subsequently a digitalized image is divided into connected segments which ar ...


8
Mary E Brown, Lance S Kuhn, Robert J McEnroe, Rebecca W Muddiman, Mary L Ochs: Electrochemical enzymatic complementation immunoassay. Boehringer Mannheim Corporation, Boehringer Mannheim, D Michael Young, Max J Kenemore, Marilyn L Amick, June 27, 1995: US05427912 (22 worldwide citation)

An immunoassay diagnostic kit, method, and apparatus for electrochemically determining the concentration of an analyte in a sample. A mixture is formed which includes the sample, an enzyme-acceptor polypeptide, an enzyme-donor polypeptide linked to an analyte analog (enzyme-donor polypeptide conjuga ...


9
Elke Faatz, Urban Schmitt: Antigen-specific IgG detection. Roche Diagnostics, Marilyn L Amick, Roche Diagnostics Corporation, November 11, 2003: US06645732 (22 worldwide citation)

The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin G class in the presence of immunoglobulins of the M class in body fluids by incubation with at least two different receptors R


10
Wolfgang Hosel, Helmut Lenz, Jochen Peter: Purification of substances from a biological sample. Roche Diagnostics, Marilyn L Amick, Roche Diagnostics Corporation, October 21, 2003: US06635420 (20 worldwide citation)

The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the binding pair in a free form. In addition reagent k ...