1
Vincent Divino Jr, Seth A Foerster, James M Gessert, Robert A Mest, Paul J Zalesky: Apparatus for the preparation and delivery of gas-enriched fluids. TherOx, Margaret A Kivinski, September 24, 2002: US06454997 (115 worldwide citation)

A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that re ...


2
Vincent Divino Jr, Seth A Foerster, James M Gessert, Robert A Mest, Paul J Zalesky, James Richard Spears: Method for the preparation and delivery of gas-enriched fluids. TherOx, Wayne State University, Margaret A Kivinski, January 13, 2004: US06676900 (66 worldwide citation)

A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that re ...


3
Vincent Divino Jr, Paul J Zalesky, William R Patterson: Method for blood oxygenation. TherOx, Margaret A Kivinski, July 22, 2003: US06596235 (66 worldwide citation)

An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a firs ...


4
Michael Bell: Automated random access analyzer. Beckman Instruments, William H May, Gary T Hampson, Margaret A Kivinski, October 21, 1997: US05679309 (61 worldwide citation)

An improved automated diagnostic analyzer and method of the type which includes a reaction carousel having cuvettes to receive sample and reactant for photometric analysis and to index and park for addition of sample, reactant and washing of cuvettes. Alternative reactant and/or sample addition poin ...


5
Vincent Divino Jr, John Merritt, Seth A Foerster, William C Homet, Paul J Zalesky: Atraumatic fluid delivery devices. TherOx, Margaret A Kivinski, May 22, 2001: US06235007 (61 worldwide citation)

The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferr ...


6
William R Patterson, Stephen E Myrick, Vincent Divino Jr, Jeffrey L Creech, Mark S Buhr: Method of blood oxygenation. TherOx, Margaret A Kivinski, May 20, 2003: US06565807 (59 worldwide citation)

An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atom ...


7
Daw J Derek, Jeffrey L Creech, William R Patterson: Bubble detector and method of use thereof. TherOx, Margaret A Kivinski, September 23, 2003: US06622542 (59 worldwide citation)

A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, th ...


8
J Richard Spears, Richard Crilly, Ray Rydman, James Gessert, Steve Myrick: Apparatus for oxygenating wastewater. Wayne State University, TherOx, DynamOx, Margaret A Kivinski, March 7, 2006: US07008535 (54 worldwide citation)

A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to form gas-enriched wastewater. The ga ...


9
Daw J Derek, William R Patterson, Stephen E Myrick, Jeffrey L Creech, Vincent Divino Jr, Gregory P Watson, Paul J Zalesky: System for enriching a bodily fluid with a gas. TherOx, Margaret A Kivinski, June 24, 2003: US06582387 (52 worldwide citation)

A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages ...


10
J Richard Spears: Stabilized gas-enriched and gas-supersaturated liquids. Wayne State University, Margaret A Kivinski, February 5, 2002: US06344489 (52 worldwide citation)

A gas-enriched liquid delivered at a site of interest that is substantially bubble free after delivery into a lower pressure liquid or gas environment. The delivered gas-enriched liquid is produced by a process comprising the steps of: