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Gregory A Demopulos, Pamela Pierce Palmer, Jeffrey M Herz: Compositions and methods for systemic inhibition of cartilage degradation. Omeros Corporation, Omeros Corporation, Marcia S Kelbon, June 27, 2006: US07067144 (43 worldwide citation)

Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also ...


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Gregory A Demopulos, Pamela Pierce Palmer, Jeffrey M Herz: Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors. Omeros Corporation, Omeros Corporation, Marcia S Kelbon, August 15, 2006: US07091181 (13 worldwide citation)

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one tumor necrosis factor (TNF) soluble receptor at dilute concentration in a physi ...


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Jun Li, Xu Li, Xiping Ni, Kam W Leong: Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from. Omeros Corporation, Institute of Materials Research and Engineering, Marcia S Kelbon, November 20, 2007: US07297348 (9 worldwide citation)

A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent ...


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Gregory A Demopulos, Scott W Reed, Alan B Bachman, Frederick T Karl, William J Allen, Leland Ray Adams, G Lawrence Thatcher: Soft tissue repair system. Marcia S Kelbon, August 30, 2011: US08006700 (8 worldwide citation)

A medical fastener (18), preferably bioabsorbable, is used for repairing torn soft tissue, particularly meniscal tissue (16). The fastener (18) can have an enlarged head (22) at the proximate end to engage meniscal tissue (16) adjacent to a tear (14), and a pointed distal tip (21) at the other end t ...


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Gregory A Demopulos, Pamela Pierce Palmer, Jeffrey M Herz: Ophthalmologic irrigation solutions and method. Omeros Corporation, Marcia S Kelbon, May 8, 2012: US08173707 (6 worldwide citation)

Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein ...


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Jens Chr Jensenius, Steffen Thiel: MASP 2, a complement-fixing enzyme, and uses for it. Helion Biotech ApS, Tineka J Quinton, Marcia S Kelbon, October 8, 2013: US08551790 (5 worldwide citation)

The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway.


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Hans Wilhelm Schwaeble, Thomas Dudler, Clark E Tedford, James B Parent, Gregory A Demopulos: Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation. Omeros Corporation, University of Leicester, Tineka J Quinton, Marcia S Kelbon, February 18, 2014: US08652477 (5 worldwide citation)

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular ...


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Gregory A Demopulos, Pamela Pierce Palmer, Jeffrey M Herz: Ophthalmologic irrigation solutions and method. Omeros Corporation, Marcia S Kelbon, November 19, 2013: US08586633 (5 worldwide citation)

Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein ...


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W Jason Cummings, Munehisa Yabuki, John B Leppard, Christi L Wood, Nancy Maizels, Daniel S Allison, Larry W Tjoelker: Anti-FZD10 monoclonal antibodies and methods for their use. Omeros Corporation, Tinika J Quinton, Marcia S Kelbon, August 11, 2015: US09102724 (4 worldwide citation)

The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of emb ...