1
Defrees Shawn: Intracellular formation of peptide conjugates. Neose Technologies, Defrees Shawn, MANN Jeffry S, October 28, 2004: WO/2004/091499 (61 worldwide citation)

The invention includes methods and compositions for forming peptide conjugates intracellularly having a covalent linkage between a modifying group and a glycosylated or non-glycosylated peptide. The modifying group is conjugated to the peptide via a glycosyl linking group interposed between and cova ...


2
Raymond Kenneth N, Seitz Michael: 2-hydroxy-1-oxo 1,2 dihydro isoquinoline chelating agents. The Regents Of The University Of California, Raymond Kenneth N, Seitz Michael, MANN Jeffry S, October 25, 2007: WO/2007/121453 (52 worldwide citation)

The invention provides a new class of strongly chelating multidentate ligands based on a 2-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid scaffold (hereafter 1,2-HOIQO) in combination with polyamine backbones. The extremely stable bidentate 1,2- HOIQO moiety can be synthesized by standard ...


3
De, Frees Shawn, Zopf David, Bayer Robert, Bowe Caryn, Hakes David, Chen Xi: Glycopegylation methods and proteins/peptides produced by the methods. Neose Technologies, de, Frees Shawn, Zopf David, Bayer Robert, Bowe Caryn, Hakes David, Chen Xi, MANN Jeffry S, November 18, 2004: WO/2004/099231 (47 worldwide citation)

The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.


4
Defrees Shawn, Kinealy Kyle: Methods for the purification of polypeptide conjugates. Neose Technologies, Defrees Shawn, Kinealy Kyle, MANN Jeffry S PhD, May 15, 2008: WO/2008/057683 (47 worldwide citation)

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylen ...


5
Defrees Shawn, Clausen Henrik: Compositions and methods for the preparation of human growth hormone glycosylation mutants. Neose Technologies, Defrees Shawn, Clausen Henrik, MANN Jeffry S, December 2, 2004: WO/2004/103275 (43 worldwide citation)

The present invention relates to mutants of human growth hormone, which contain newly introduced N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. ...


6
Defrees Shawn, Clausen Henrik, Zopf David A, Bowe Caryn, Taudte Susann, Felo Michael, Willett Walter S: Glycopegylated granulocyte colony stimulating factor. Neose Technologies, Defrees Shawn, Clausen Henrik, Zopf David A, Bowe Caryn, Taudte Susann, Felo Michael, Willett Walter S, MANN Jeffry S, July 13, 2006: WO/2006/074467 (36 worldwide citation)

The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glyc ...


7
Defrees Shawn, Bayer Robert J, Bowe Caryn: Glycopegylated follicle stimulating hormone. Neose Technologies, Defrees Shawn, Bayer Robert J, Bowe Caryn, MANN Jeffry S, June 23, 2005: WO/2005/056760 (35 worldwide citation)

The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated ...


8
Defrees Shawn: Branched water-soluble polymers and their conjugates. Neose Technologies, Defrees Shawn, MANN Jeffry S, September 30, 2004: WO/2004/083258 (33 worldwide citation)

The present invention provides branched water-soluble polymers that allow two or more water-soluble polymers to be conjugated to another species. The branched polymers provide access to therapeutic agents that are conjugated at a single site to two or more water-soluble polymers. The branched polyme ...


9
Defrees Shawn, Bowe Caryn: Improved process for the production of nucleotide sugars. Neose Technologies, Defrees Shawn, Bowe Caryn, MANN Jeffry S, December 18, 2008: WO/2008/154639 (32 worldwide citation)

The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the inventio ...


10
Defrees Shawn, Bowe Caryn: Branched polymeric sugars and nucleotides thereof. Neose Technologies, Defrees Shawn, Bowe Caryn, MANN Jeffry S, August 11, 2005: WO/2005/072371 (31 worldwide citation)

The present invention provides sugars, nucleotide sugars, activated sugars that include one or more polymeric modifying moiety within their structure. The invention is exemplified by reference to linear and branched polymers, such as the water-soluble polymer poly(ethylene glycol).