1
John L Haslam, Takeru Higuchi, Arthur R Mlodozeniec: Drug delivery system utilizing thermosetting gels. Merck & Co, Manfred Polk, Michael C Sudol Jr, October 23, 1984: US04478822 (224 worldwide citation)

This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.


2
John L Haslam, Takeru Higuchi, Arthur R Mlodozeniec: Ophthalmic drug delivery system utilizing thermosetting gels. Merck & Co, Manfred Polk, Michael C Sudol Jr, October 2, 1984: US04474751 (170 worldwide citation)

This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree ...


3
John L Haslam, Takeru Higuchi, Arthur R Mlodozeniec: Drug delivery system utilizing thermosetting gels. Merck & Co, Manfred Polk, Michael C Sudol Jr, October 2, 1984: US04474752 (140 worldwide citation)

Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.


4
Larry J Caldwell, Colin R Gardner, Robyn C Cargill: Drug delivery device which can be retained in the stomach for a controlled period of time. Merck & Co, Manfred Polk, Michael C Sudol, August 30, 1988: US04767627 (127 worldwide citation)

A drug delivery device retained in the stomach comprising a planar figure made from an erodible polymer that may release a drug associated therewith over a controlled, predictable and extended period of time.


5
Jacob A Zupan: Use of eucalyptol for enhancing skin permeation of bio-affecting agents. Merck & Co, Manfred Polk, Michael C Sudol Jr, Mario A Monaco, April 3, 1984: US04440777 (85 worldwide citation)

Greatly enhanced delivery of a wide variety of bio-affecting agents is provided by formulations for topical application comprising at least one bio-affecting agent and eucalyptol. Optionally, the formulation can further comprise a non-toxic topical carrier and/or an additional penetration enhancer. ...


6
John L Haslam, Takeru Higuchi, Arthur R Mlodozeniec: Topical drug delivery system utilizing thermosetting gels. Merck & Co, Manfred Polk, Michael C Sudol Jr, October 2, 1984: US04474753 (78 worldwide citation)

This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.


7
Jose Alexander: (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs. Merck & Co, Manfred Polk, Michael C Sudol, July 26, 1988: US04760057 (76 worldwide citation)

This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function thereon. Hydrolytic enzymes are used to trigger the regeneration of the parent amine drug of the carba ...


8
Takeru Higuchi, Toshiaki Nishihata: Method of increasing oral absorption of polar bioactive agents. INTERx Research, Manfred Polk, Michael C Sudol Jr, July 31, 1984: US04462991 (74 worldwide citation)

A method and drug form are provided for increasing the oral absorption of polar bioactive agents such as polypeptides by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaromatic acid or salt as an adjuvant ther ...


9
Jose Alexander: Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs. Merck & Co, Manfred Polk, Joseph F DiPrima, April 10, 1990: US04916230 (47 worldwide citation)

This invention relates to a new one-step process for preparation of novel N-(acyloxyalkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for drugs having a primary or secondary amine function thereon.


10
A J Repta: Rectally absorbable form of L-dopa. Merck & Co, Manfred Polk, Michael C Sudol Jr, May 5, 1987: US04663349 (33 worldwide citation)

The invention relates to compositions and methods of enhancing rectal absorption of L-dopa via the formation of an ester prodrug and optionally with a decarboxylase inhibitor.