1
Theeuwes Felix, Higuchi Takeru: Osmatic dispensing device for releasing beneficial agent. Alza Corporation, Sabatine Paul L, Mandell Edward L, Benz William H, November 5, 1974: US3845770 (1481 worldwide citation)

A wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the composition is disclosed. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in the fluid and exhibits ...


2
Theeuwes Felix, Higuchi Takeru: Osmotic dispensing device with maximum and minimum sizes for the passageway. Alza Corporation, Sabatine Paul L, Mandell Edward L, Ciotti Thomas E, November 4, 1975: US3916899 (1286 worldwide citation)

A device is disclosed comprised of a wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the compostion. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in th ...


3
Zaffaroni Alejandro: Drug-delivery system. Alza Corporation, Mandell Edward L, Ciotti Thomas E, Sabatine Paul L, December 17, 1974: US3854480 (319 worldwide citation)

Drug-delivery system for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having solid particles of drug dispersed therethrough. Surrounding the inner matrix is an outer polymeric membrane, insoluble in body fluids. Both the inner matrix ...


4
Zaffaroni Alejandro: Novel drug delivery device. Alza Corporation, Ciotti Thomas E, Sabatine Paul L, Mandell Edward L, November 25, 1975: US3921636 (292 worldwide citation)

A drug delivery device for administering drug at a controlled rate for a prolonged period of time is disclosed. The device comprises a plurality of reservoirs containing drug distributed through a matrix. The reservoirs and the matrix are formed of materials permeable to passage of drug. The rate of ...


5
Michaels Alan S, Buckles Richard G, Keller Michael P: Ultrasonic nebulizer. Ciotti Thomas E, Mandell Edward L, Sabatine Paul L, May 28, 1974: US3812854 (194 worldwide citation)

A device for the ultrasonic nebulization of liquids. Nebulization takes place in a porous solid body the porosity of which determines the size of the liquid particles generated. The device is especially suitable for nebulizing liquid medicaments for inhalation therapy.


6
Theeuwes Felix: Electroosmotic pump and fluid dispenser including same. Alza Corporation, Ciotti Thomas E, Sabatine Paul L, Mandell Edward L, December 2, 1975: US3923426 (180 worldwide citation)

A miniature electroosmotic pump and fluid dispenser including the pump are disclosed. The pump comprises a plexiglass housing having a fluid inlet and outlet, a pair of spaced silver-silver chloride electrodes disposed in the housing and connected to a d.c. power source, a porous ceramic plug which ...


7
Hoff Seymour, Kehr Sharon A, Pharriss Bruce B: Apparatus for inserting an intrauterine device. ALZA Corporation, Ciotti Thomas E, Sabatine Paul L, Mandell Edward L, November 11, 1975: US3918444 (112 worldwide citation)

An intrauterine device comprising a stem and at least one arm depending therefrom, such as the 'Tatum T,' and apparatus for inserting it into the uterine cavity, the insertion apparatus being (1) a curved elongated inserter tube on one end of which the intrauterine device is fixedly mounted with its ...


8
Heller Jorge, Baker Richard W: Bioerodible ocular device. Alza Corporation, Ciotti Thomas E, Mandell Edward L, Sabatine Paul L, May 21, 1974: US3811444 (103 worldwide citation)

An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The insert comprises a drug formulation dispersed through a body of selected hydrophobic polycarboxylic acids which erode in the envir ...


9
Ramwell Peter W: Erodible intrauterine device. Alza Corporation, Sabatine Paul L, Benz William H, Mandell Edward L, June 10, 1975: US3888975 (103 worldwide citation)

An intrauterine device for administering drug locally to the uterus at a controlled rate for a prolonged period of time is disclosed. The device contains a body of polymer capable of bioeroding in the environment of the uterus over a prolonged period of time. This body has the drug dispersed through ...


10
Michaels Alan S, Buckles Richard G, Yum Su Il: Self-powered vapor pressure delivery device. ALZA Corporation, Ciotti Thomas E, Sabatine Paul L, Mandell Edward L, October 8, 1974: US3840009 (97 worldwide citation)

A self-powered vapor pressure delivery device for the controlled and continuous dispensing of an active agent employing in a preferred embodiment outer and inner chambers in functional relationships. The inner chamber is a sealed bag comprised of a flexible and substantially vapor and fluid impermea ...