1
Beltran Pedro J, Calzone Frank J, Friberg Gregory, Haqq Christopher, Tolcher Anthony W: Methods and compositions for treating tumor diseases. Amgen, Beltran Pedro J, Calzone Frank J, Friberg Gregory, Haqq Christopher, Tolcher Anthony W, MACHIN Nathan, September 12, 2008: WO/2008/108986 (27 worldwide citation)

The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments ...


2
Calzone Frank J, Deshpande Rajendra V, Tsai Mei Mei: Compositions comprising anti-igf-i receptor antibodies and methods for obtaining said antibodies. Amgen, Calzone Frank J, Deshpande Rajendra V, Tsai Mei Mei, MACHIN Nathan A, June 29, 2006: WO/2006/069202 (23 worldwide citation)

The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti­IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies ...


3
Carter Paul J, Zhou Hongxing: Antibodies that bind interleukin-4 receptor. Immunex Corporation, Carter Paul J, Zhou Hongxing, MACHIN Nathan A, May 26, 2005: WO/2005/047331 (12 worldwide citation)

The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic ...


4
Kim Kristine M, Wiley Steven R, Ketchem Randal R, Fanslow Iii William C: Tweak receptor. Immunex Corporation, Kim Kristine M, Wiley Steven R, Ketchem Randal R, Fanslow Iii William C, MACHIN Nathan A, May 4, 2006: WO/2006/047172 (6 worldwide citation)

The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as so ...


5
Wiley Steven R: Compositions and methods relating to multimeric and oligomeric soluble fragments of the tweak receptor. Amgen, Wiley Steven R, MACHIN Nathan A, February 3, 2005: WO/2005/010045 (5 worldwide citation)

The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenes ...


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Aldrich Teri, Shen Wenyan, Jacobsen Frederick W, Morris Arvia E, Allen Martin J: Monkey immunoglobulin sequences. Amgen, Aldrich Teri, Shen Wenyan, Jacobsen Frederick W, Morris Arvia E, Allen Martin J, MACHIN Nathan A, May 26, 2005: WO/2005/047325 (5 worldwide citation)

Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain constant regions derived from cynomolgus monkeys. Chimeric antibodies with cynomolgus monkey constant regions are described.


8
MCCAFFERY Ian, LU Jian Feng: MÉTHODES ET COMPOSITIONS ASSOCIÉES À LINHIBITION DIGF-1R, METHODS AND COMPOSITONS RELATING TO INHIBITION OF IGF-1R. AMGEN, MCCAFFERY Ian, LU Jian Feng, MACHIN Nathan, August 9, 2012: WO/2012/106556 (1 worldwide citation)

The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments ...


9
Fanslow Iii William C, Rousseau Anne Marie C, Daniel Thomas O: Endothelial stem cells, populations, methods of isolation and use thereof. Immunex Corporation, Fanslow Iii William C, Rousseau Anne Marie C, Daniel Thomas O, MACHIN Nathan A, July 24, 2003: WO/2003/060077

The present invention provides stem cells characterized as having the ability to renew and the ability to give rise to endothelial and/or endothelial-like cells, methods of isolating such stem cells and methods of use thereof. Also provided are progeny cells derived from the stem cells of the invent ...


10
Rothenberg Marc: Compositions and methods relating to gastrointestinal allergic conditions. Childrens Hospital Medical Center, Rothenberg Marc, MACHIN Nathan, September 17, 2009: WO/2009/114828

The present invention relates to methods and compositions for treating gastrointestinal allergic diseases. Such treatments include, for example, prophylactic methods. Examples of prophylactic methods include methods that prevent the onset, or reduce the likelihood of the onset, or reduce the duratio ...