1
Stephanie L Castro, Emilio Barbera Guillem: Functionalized nanocrystals and their use in detection systems. BioCrystal, M Bud Nelson, September 5, 2000: US06114038 (222 worldwide citation)

Provided are compositions comprising water-soluble, functionalized nanocrystals. The water-soluble functionalized nanocrystals comprise quantum dots capped with a layer of a capping compound, and further comprise, by operably linking and in a successive manner, one or more additional compounds. The ...


2
Emilio Barbera Guillem, M Bud Nelson, Stephanie L Castro: Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system. Bio Pixels, M Bud Nelson, July 17, 2001: US06261779 (115 worldwide citation)

Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands w ...


3
Emilio Barbera Guillem: Fluorescent nanocrystal-labeled microspheres for fluorescence analyses. Bio Pixels, M Bud Nelson, October 30, 2001: US06309701 (92 worldwide citation)

Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals operably bound to a polymeric microsphere, and a method of producing the fluorescent microspheres which comprises contacting the polymeric microsphere with a plurality of fluorescent nanocrystals under suitab ...


4
Emilio Barbera Guillem, Marlin O Thurston: Continuous flow process for production of semiconductor nanocrystals. BioCrystal, M Bud Nelson, January 30, 2001: US06179912 (89 worldwide citation)

Provided is a system and continuous flow process for producing monodisperse semiconductor nanocrystals comprising reservoirs for the starting materials, a mixing path in which the starting materials are mixed, a first reactor in which the mixture of starting materials is mixed with a coordinating so ...


5
Emilio Barbera Guillem: Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging. Bio Pixels, M Bud Nelson, December 25, 2001: US06333110 (77 worldwide citation)

Provided is a method of fluorescence imaging of living tissue using functionalized nanocrystals. The method comprises contacting an effective amount of functionalized nanocrystals with the living tissue; exposing the tissue to a spectrum of light suitable for exciting functionalized nanocrystals, pr ...


6
Emilio Barbera Guillem, M Bud Nelson, Stephanie L Castro: Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination. Bio Pixels, M Bud Nelson, April 24, 2001: US06221602 (54 worldwide citation)

Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities. Also provided are kits comprising a plurality of species of functionalized nanocrystal-labeled nucleoba ...


7
Emilio Barbera Guillem, Rick D Lucas: Microincubator comprising a cell culture apparatus and a transparent heater. BioCrystal, M Bud Nelson, April 29, 2003: US06555365 (46 worldwide citation)

Provided for heating cultured cells is a controlled heater device comprising a cell culture apparatus, a transparent heater in thermal contact with the cell culture apparatus, and may further comprise one or more of a transparent filter provided to prevent a predetermined spectral range of light fro ...


8
Emilio Barbera Guillem: Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors. BioCrystal, M Bud Nelson, May 1, 2001: US06224866 (40 worldwide citation)

A method for treating a pro-tumor immune response in an individual having, or suspected of having, a pro-tumor immune response, by administering a therapeutically effective amount of an immunotherapeutic composition which binds to a determinant on B cells, resulting in B cell depletion including of ...


9
Emilio Barberá Guillem: Fluorescence filter cube for fluorescence detection and imaging. BioCrystal, M Bud Nelson, June 26, 2001: US06252664 (37 worldwide citation)

A fluorescence cube comprising a housing; an exciter filter which allows passage of an incident light comprising a spectral range of from about 200 nanometers to about 400 nanometers; and either a beam splitter or a dichroic mirror which directs the incident light in a desired direction, and which t ...


10
Emilio Barbera Guillem, Stephanie L Castro: Purification of functionalized fluorescent nanocrystals. Bio Pixels, M Bud Nelson, November 20, 2001: US06319607 (30 worldwide citation)

Provided are methods for purifying functionalized fluorescent nanocrystals having affinity ligand operably bound thereto by using a solid support matrix in a reactor through which solutions are circulated, and by using an immobilized solid phase formed by operably binding functionalized fluorescent ...