1
Kath John Charles, Luzzio Michael Joseph: Pyrimidine derivates for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, LUMB J Trevor, July 8, 2004: WO/2004/056786 (148 worldwide citation)

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, n, A and B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compound ...


2
Flamme Cathlin Marie, Mcnamara Dennis Joseph, Repine Joseph Thomas, Toogood Peter Laurence, Vanderwel Scott Norman, Warmus Joseph Scott: 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation. Warner Lambert Company, Flamme Cathlin Marie, Mcnamara Dennis Joseph, Repine Joseph Thomas, Toogood Peter Laurence, Vanderwel Scott Norman, Warmus Joseph Scott, LUMB J Trevor, August 5, 2004: WO/2004/065378 (90 worldwide citation)

The present invention provides substituted 2-aminopyridines of formula (I), wherein R1, A1, W, X, and Y are as defined in the specification, useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (Cdk4).


3
Changelian Paul Steven: Method of treatment of transplant rejection. Pfizer Products, Changelian Paul Steven, LUMB J Trevor, June 10, 2004: WO/2004/047843 (75 worldwide citation)

A method of treating or preventing chronic organ transplant rejection comprising administering a compound of the formula (I), wherein R?1¿, R?2¿ and R?3¿ are as defined above.


4
Johnson Adam Richard: Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors. Warner Lambert Company, Johnson Adam Richard, LUMB J Trevor, February 19, 2004: WO/2004/014384 (45 worldwide citation)

This invention provides compounds defined by Formula I Z-L-R1-Q-D-(V1)m-R2 I or a pharmaceutically acceptable salt thereof, wherein Z, L, R1, Q, D, V1, m, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I and the us ...


5
Hulin Bernard: Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides. Pfizer Products, Hulin Bernard, LUMB J Trevor, June 3, 2004: WO/2004/046106 (41 worldwide citation)

The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, suc ...


6
Rogers Bruce Nelsen, Piotrowski David Walter, Margolis Brandon Jerome, Myers Jason Kenneth, Groppi Vincent Edward Jr, Rudmann Daniel Gregory: Positive allosteric modulators of the nicotinic acetylcholine receptor. Pharmacia & Upjohn Company, Rogers Bruce Nelsen, Piotrowski David Walter, Margolis Brandon Jerome, Myers Jason Kenneth, Groppi Vincent Edward Jr, Rudmann Daniel Gregory, LUMB J Trevor, October 7, 2004: WO/2004/085433 (41 worldwide citation)

The invention provides compounds of Formula (I). These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which &agr;7 nAChR is known to be involved.


7
Ripin David Harold Brown: 3-amino-piperidine derivatives and processes for their preparation. Pfizer Products, Ripin David Harold Brown, LUMB J Trevor, June 3, 2004: WO/2004/046112 (36 worldwide citation)

This invention relates to 3-amino piperadine derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formulas (la) and (lb) wherein R,, R2, R3, R4, R,4, and n are herein defined. The present invention also relates to th ...


8
Barvian Nicole Chantel, Kolz Christine Nylund, Para Kimberly Suzanne, Patt William Chester, Visnick Melean: Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k. Warner Lambert Company, Barvian Nicole Chantel, Kolz Christine Nylund, Para Kimberly Suzanne, Patt William Chester, Visnick Melean, LUMB J Trevor, June 24, 2004: WO/2004/052373 (36 worldwide citation)

The present invention provides compounds of Formula (I) wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R1O, R12, G, and the double bond denoted '*' have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of d ...


9
Roach Marsha Lynn, Hambor John Edward: Hepatocyte differentiation of stem cells. Pfizer Products, Roach Marsha Lynn, Hambor John Edward, LUMB J Trevor, October 14, 2004: WO/2004/087896 (36 worldwide citation)

The present invention relates to methods of culturing stem cells to produce hepatocyte-like cells. Among other advances, the invention also relates to purified preparations of hepatocyte-like celles and methods for using the hepatocyte-like cells.


10
Arcari Joel Thomas, Chen Jinshan, Lagreca Susan, Marx Matthew Arnold, Wessel Matthew David: Pyrrolopyrimidine derivatives. Pfizer Products, Arcari Joel Thomas, Chen Jinshan, Lagreca Susan, Marx Matthew Arnold, Wessel Matthew David, LUMB J Trevor, July 8, 2004: WO/2004/056830 (34 worldwide citation)

The invention relates to compounds of the formula 1or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hype ...