1
Solomon S Steiner, Trent A Poole, Per B Fog, Roderike Pohl, Michael Crick, Robert Feldstein: Unit dose cartridge and dry powder inhaler. MannKind Corporation, Louis C Cullman, Michelle S Glasky, K&L Gates, December 16, 2008: US07464706 (51 worldwide citation)

A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a ...


2
Li Chien Hsu, Can B Hu, Sun De Tong: Universal biocompatible coating platform for medical devices. Edwards Lifesciences, Louis C Cullman, October 30, 2001: US06309660 (49 worldwide citation)

Universal, biocompatible coating platforms for articles intended to contact physiological fluids or tissues and associated methods of production are disclosed. The coating platforms of the present invention are composed of a polyelectrolyte molecular film containing one or more biologically active c ...


3
Eugene Tedeschi, Chirag B Shah: Uses for medical devices having a lubricious, nitric oxide-releasing coating. Medtronic AVE, Louis C Cullman, Oppenheimer Wolff & Donnelly, April 30, 2002: US06379691 (39 worldwide citation)

Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of ...


4
Herriot Tabuteau, Eric K H Dinkla: Therapeutic compositions comprising imidazole and imidazolium compounds. Antecip Bioventures II, K&L Gates, Louis C Cullman, Brent A Johnson, October 21, 2014: US08865757 (37 worldwide citation)

Therapeutic compositions comprising at least two substituted imidazole or imidazolium compounds may be used for a number of medical purposes, such as treatment of undesirable conditions or diseases, including disease or conditions related to bone, cancer, and/or pain.


5
Herriot Tabuteau: Therapeutic compositions comprising imidazole and imidazolium compounds. Antecip Bioventures II, K&L Gates, Louis C Cullman, Brent A Johnson, December 2, 2014: US08901161 (37 worldwide citation)

Therapeutic compositions comprising at least two substituted imidazole or imidazolium compounds may be used for a number of medical purposes, such as treatment of undesirable conditions or diseases, including disease or conditions related to bone, cancer, and/or pain.


6
Herriot Tabuteau: Substituted imidazolium compounds for treating disease. Antecip Bioventures II, K&L Gates, Louis C Cullman, Brent A Johnson, December 2, 2014: US08901162 (36 worldwide citation)

The present disclosure relates to therapeutic compositions comprising substituted imidazoliums having multiple acidic groups. The compounds may be used to treat diseases or conditions such as those associated with bone, cancer, or pain. Compositions, dosage forms, methods of treating diseases or con ...


7
Peter Richardson, Robert A Baughman, Elizabeth Potocka, Anders Hasager Boss, Richard Petrucci: Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin. MannKind Corporation, K&L Gates, Louis C Cullman, Brent A Johnson, February 21, 2012: US08119593 (35 worldwide citation)

Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.


8
Anthony L Fitzhugh, Robert Cafferata, Larry K Keefer: Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use. Medtronic AVE, United States of America, Louis C Cullman, Oppenheimer Wolff & Donnelly, March 9, 2004: US06703046 (35 worldwide citation)

Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release N ...


9
John M Polo, Thomas W Dubensky Jr, Stephen F Hardy, Silvia Perri: Compositions and methods for packaging of alphavirus vectors. Chiron Corporation, Louis C Cullman, Anne S Dollard, Robert P Blackburn, December 11, 2001: US06329201 (34 worldwide citation)

Nucleic acid molecule are provided comprising a nucleic acid sequence which encodes, in order, an alphavirus capsid, a signal peptide, and an alphavirus E1 or E2 glycoprotein. Also provided are vectors encoding such nucleic acid molecules, and use of such vectors or expression cassettes to generate ...


10
Herriot Tabuteau: Substituted imidazolium compounds for treating disease. Antecip Bioventures II, K&L Gates, Louis C Cullman, Brent A Johnson, September 16, 2014: US08835650 (33 worldwide citation)

The present disclosure relates to therapeutic compositions comprising substituted imidazoliums having multiple acidic groups. The compounds may be used to treat diseases or conditions such as those associated with bone, cancer, or pain. Compositions, dosage forms, methods of treating diseases or con ...