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Acton Paul, An Zhiqiang, Bett Andrew J, Breese Robert, Dodson Elizabeth Chen, Kinney Gene, Klein William, Lambert Mary P, Liang Xiaoping, Shughrue Paul, Strohl William R, Viola Kirsten L, Chang Lei: Anti-addl antibodies and uses thereof. Merck & Co, Northwestern University, Acton Paul, An Zhiqiang, Bett Andrew J, Breese Robert, Dodson Elizabeth Chen, Kinney Gene, Klein William, Lambert Mary P, Liang Xiaoping, Shughrue Paul, Strohl William R, Viola Kirsten L, Chang Lei, LICATA Jane Massey, May 26, 2006: WO/2006/055178 (58 worldwide citation)

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A&bgr;-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer’s Disease and control human brain extracts and are useful in methods ...


2
Kinney Gene, Strohl William R, An Zhiqiang: Anti-addl monoclonal antibody and use thereof. Merck & Co, Kinney Gene, Strohl William R, An Zhiqiang, LICATA Jane Massey, May 3, 2007: WO/2007/050359 (32 worldwide citation)

The present invention relates to antibodies that -differentially -recognize- -multi- dimensional conformations- of- A&bgr;- derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in ...


3
Pilkington Glenn, Keller Gilbert Andre, Li Wenlu, Corral Laura, Simon Iris, Papkoff Jackie: Ovr110 antibody compositions and methods of use. Diadexus, Pilkington Glenn, Keller Gilbert Andre, Li Wenlu, Corral Laura, Simon Iris, Papkoff Jackie, LICATA Jane Massey, November 25, 2004: WO/2004/101756 (20 worldwide citation)

The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided ...


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HONDA TADASHI: Betulinic acid derivatives and methods of use thereof. Trustees Of Dartmouth College, Licata Jane Massey, May 14, 2010: WO/2010/053817 (19 worldwide citation)

This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment met ...


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Coifman Robert E: Devices for measuring inspiratory airflow. Coifman Robert E, LICATA Jane Massey, June 9, 2005: WO/2005/051177 (13 worldwide citation)

New applications of unidirectional airflow sensing in devices which measure inspiratory airflow and bidirectional airflow are provided. Such devices can be used for administration of a medication via inhalation, in spirometers and in devices which measure and monitor respiratory ventilation.


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Liu Shu Hui, Papkoff Jackie: Ovr232v3 antibody compositions and methods of use. Diadexus, Liu Shu Hui, Papkoff Jackie, LICATA Jane Massey, February 8, 2007: WO/2007/016590 (11 worldwide citation)

The invention provides isolated anti-ovarian, colon, prostate, or lung cancer antigen (Ovr232v3) antibodies that bind to Ovr232v3 on a mammalian cell. The invention also encompasses compositions containing an anti-Ovr232v3 antibody and a carrier. These compositions can be provided in an article of m ...


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Howitz Konrad T, Zipkin Robert E: Compositions and methods for selectively activating human sirtuins. Biomol Research Laboratories, Howitz Konrad T, Zipkin Robert E, LICATA Jane Massey, January 12, 2006: WO/2006/004722 (10 worldwide citation)

Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.


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ROESCH ALEXANDER O: Compositions containing jarid1b inhibitors and methods for treating cancer. THE WISTAR INSTITUTE, Licata Jane Massey, February 10, 2011: WO/2011/017583 (10 worldwide citation)

The present invention features compositions and methods for treating cancers such as melanoma, which have a subpopulation of self -renewing JARIDIB-positive cells essential to maintenance and metastatic progression of the cancer.


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Kahn Nighat N, Sinha Asru K: Nitric oxide inducing agents. Kahn Nighat N, Sinha Asru K, LICATA Jane Massey, August 5, 2004: WO/2004/064767 (9 worldwide citation)

The present invention provides a method to promote the production of nitric oxide in cells found in the epidermal layer. The method is effective to prevent and treat a wide range of cancers. The method is also effective for promoting pain relief and controlling diabetes in patients.


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Kahn Nighat N, Sinha Asru K: Compositions and method for modulating insulin-activated nitric oxide synthase. Kahn Nighat N, Sinha Asru K, LICATA Jane Massey, December 8, 2005: WO/2005/115440 (9 worldwide citation)

Compositions and methods are provided for increasing nitric oxide synthesis in cells or tissues through use of a non-insulin protein. The uses of the composition include treatment of cancer and diabetes mellitis.