1
Roger S Cubicciotti: Methods for detecting and identifying single molecules. Molecular Machines, Licata & Tyrrell P C, September 11, 2001: US06287765 (214 worldwide citation)

Multimolecular devices and drug delivery systems prepared from synthetic heteropolymers, heteropolymeric discrete structures, multivalent heteropolymeric hybrid structures, aptameric multimolecular devices, multivalent imprints, tethered specific recognition devices, paired specific recognition devi ...


2
Shane Farritor, Dmitry Oleynikov, Stephen R Platt, Mark Rentschler, Jason Dumpert: Robot for surgical applications. Board of Regents of the University of Nebraska, Licata & Tyrrell P C, October 24, 2006: US07126303 (172 worldwide citation)

The present invention provides a micro-robot for use inside the body during minimally-invasive surgery. The micro-robot includes an imaging devices, a manipulator, and in some embodiments a sensor.


3
Kenneth Khaw, John K J Li: Temporary blood circulation assist device. University of Medicine and Dentristy of New Jersey, Licata & Tyrrell P C, January 3, 2006: US06981942 (81 worldwide citation)

An inflatable circulation assist device is disclosed consisting of an inflatable stator housing an impeller with inflatable blades of varying shapes and sizes. The invention is introduced into the patient percutaneously. The circulation assist device is a small pump packaged into a compact form that ...


4
C Frank Bennett, Andrew T Watt: Antisense inhibition of vascular endothelial growth factor receptor-1 expression. ISIS Pharmaceuticals, Licata & Tyrrell P C, March 23, 2004: US06710174 (72 worldwide citation)

Antisense compounds, compositions and methods are provided for modulating the expression of vascular endothelial growth factor receptor-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vascular endothelial growth factor rec ...


5
Jacqueline Wyatt: Antisense modulation of E2F transcription factor 2 expression. ISIS Pharmaceuticals, Licata & Tyrrell P C, September 3, 2002: US06444464 (66 worldwide citation)

Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 2. Methods of using these compou ...


6
Brett P Monia, Lex M Cowsert: Antisense inhibition of PKA regulatory subunit RII alpha expression. ISIS Pharmaceuticals, Licata & Tyrrell P C, February 25, 2003: US06524854 (65 worldwide citation)

Antisense compounds, compositions and methods are provided for modulating the expression of PKA regulatory subunit RII alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PKA regulatory subunit RII alpha. Methods of using ...


7
C Frank Bennett, Lex M Cowsert: Antisense modulation of calreticulin expression. ISIS Pharmaceuticals, Licata & Tyrrell P C, July 30, 2002: US06426220 (61 worldwide citation)

Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calret ...


8
Randy Gaugler, Moeen Abu Hatab: Disposable bioreactor for culturing microorganisms and cells. Rutgers the State University, Licata & Tyrrell P C, August 13, 2002: US06432698 (56 worldwide citation)

A disposable bioreactor for culturing microorganisms and cells is provided. The bioreactor is suitable for use by individuals not skilled in microbiology or aseptic technique. It is constructed of flexible or semi-flexible waterproof sheets to form a container designed to provided mixing and gas exc ...


9
Betty Wong, John E Kemnitzer: Porous constructs fabricated by gas induced phase inversion. Integra LifeSciences, Licata & Tyrrell P C, September 16, 2003: US06620356 (55 worldwide citation)

Methods for producing open-pore polymeric matrices prepared via gas induced phase inversion are provided. Matrices produced by these methods for various uses including medical implant devices, filtration/separation aids, and porous supports are also provided.


10
Cato T Laurencin, Frank K Ko: Hybrid nanofibril matrices for use as tissue engineering devices. Drexel University, Licata & Tyrrell P C, February 10, 2004: US06689166 (46 worldwide citation)

Tissue engineering devices with enhanced cell adhesion, cell proliferation and directional growth are provided which are prepared from nonwoven nanofibril matrices.



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