1
Gautam Mitra: Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer. Miles Laboratories, Lester E Johnson, January 29, 1985: US04496689 (450 worldwide citation)

There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a ...


2
Deborah A Eppstein, Brian B Schryver: Controlled release of macromolecular polypeptides. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, October 9, 1990: US04962091 (196 worldwide citation)

An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.


3
Ching Jen Chang, Travis E Stevens: Alkyl, poly(oxyethylene) poly(carbonyloxyethylene) acrylate emulsion copolymers for thickening purposes. Rohm and Haas Company, Alex R Sluzas, Lester E Johnson, December 20, 1983: US04421902 (85 worldwide citation)

There are disclosed polymerizable alkyl poly(oxyethylene) poly(carbonyloxyethylene)acrylates and copolymers thereof, especially stable, aqueous dispersions of water-insoluble emulsion copolymers of (1) about 10-70% by weight of (meth)acrylic, (2) about 0.5-25% by weight of an alkyl poly(oxyethylene) ...


4
Peter M Fernandes, John L Lundblad: Pasteurized therapeutically active protein compositions. Cutter Laboratories, Theodore J Leitereg, Lester E Johnson, April 3, 1984: US04440679 (66 worldwide citation)

Compositions containing thermally sensitive, therapeutically active proteins are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol prior to pasteurization. Pasteurized compositions containing therapeuti ...


5
William D Emmons: Ambient or low-temperature curable coatings. Rohm and Haas Company, Lester E Johnson, Robert J Steinmeyer, John E Vanderburgh, Robert S Frieman, July 1, 1980: US04210565 (51 worldwide citation)

Ambient or low-temperature curable solutions or aqueous dispersions of (1) a polymer containing units polymerized from a monomer mixture of (a) from about 0.25% to about 30% by weight of a polymerizable aldehyde, and (b) at least one copolymerizable mono-ethylenically unsaturated monomer, with (2) a ...


6
Grace C Tsay, Michael S Collins: Vaccines for gram-negative bacteria. Miles Laboratories, Lester E Johnson, Pamela A Simonton, May 5, 1987: US04663160 (49 worldwide citation)

An immunizing composition is disclosed and comprises a detoxified polysaccharide from a gram-negative bacterium covalently coupled to a detoxified protein from said gram-negative bacterium by means of a 4-12 carbon moiety. To prepare the above immunizing agent, the lipid A portion of lipopolysacchar ...


7
Robert A Tenold: Intravenously injectable immune serum globulin. Cutter Laboratories, David J Aston, Lester E Johnson, Theodore J Leitereg, February 12, 1985: US04499073 (43 worldwide citation)

A composition is disclosed which comprises a solution in a pharmaceutically acceptable carrier of an immune serum globulin, said solution having an ionic strength and a pH to maintain the monomer content and the actual and latent anticomplement activity of the immune serum globulin such that the com ...


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Calum B MacFarlane, Alastair B Selkirk, Michael J Dey: Method of preparing long acting formulation. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, July 10, 1990: US04940556 (38 worldwide citation)

A long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binde are intimately admixed in essentially spherically shaped non-rugose particles of up to 1.2 mm in diameter.


10
Gautam Mitra, Paul K Ng: Pasteurized therapeutically active blood coagulation factor concentrates. Miles Laboratories, Lester E Johnson, Theodore J Leitereg, September 11, 1984: US04470968 (36 worldwide citation)

Compositions containing a concentrate of coagulation Factors II, VII, IX, and X are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol and a source of citrate ions prior to pasteurization. Pasteurized co ...