1
Stéphane De Lombaert
Stéphane De Lombaert, Alan Hutchison, Xiaozhang Zheng: Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines. Neurogen Corporation, Lawson & Weitzen, Sonia K Guterman, September 13, 2005: US06943199 (18 worldwide citation)

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a ...


2
Stéphane De Lombaert
Raymond F Horvath, Jennifer Tran, Stéphane De Lombaert, Kevin J Hodgetts, Philip A Carpino, David A Griffith: Certain alkylene diamine-substituted heterocycles. Neurogen, Pfizer, Sonia K Guterman, Lawson & Weitzen, July 11, 2006: US07074929

This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula II, IV, V, VII–IX and XI


3
Zoltán Takáts, Bogdan Gologan, Justin Michael Wiseman, Robert Graham Cooks: Method and system for desorption electrospray ionization. Purdue Research Foundation, Lawson & Weitzen, Sonia K Guterman, Adam M Schoen, February 26, 2008: US07335897 (43 worldwide citation)

A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a ...


4
Eyal Bartfeld, Amir Lass: System and method for real time management of a drug regimen. Irody, Lawson & Weitzen, Sonia K Guterman, Teofilo Javier Jr, June 29, 2010: US07747454 (37 worldwide citation)

A system for managing a prescribed drug regimen for a user, the system including at least one electronic device (Pod) for interactive communication with at least one user, a Pod server coupled via a communication link to each Pod, said Pod server including an analysis unit, the analysis unit includi ...


5
Robert G Cooks, Bogdan Gologan, Zoltán Takáts, Justin M Wiseman, Ismael Cotte Rodriguez: Method and system for desorption atmospheric pressure chemical ionization. Purdue Research Foundation, Sonia K Guterman, Lawson & Weitzen, June 9, 2009: US07544933 (30 worldwide citation)

A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip i ...


6
Bartfeld Eyal: Method and apparatus for selecting and displaying multi-media messages. Integra5 Communications, Sonia K Guterman, Lawson & Weitzen, August 4, 2009: US07571458 (26 worldwide citation)

Apparatus and method for remote viewing of selected messages at a subscriber remote receiving location, the apparatus including at least one messaging server (such as, but not limited to, a unified messaging system, voice-mail system, fax server system, or any other message store and management syst ...


7
Ernest V Groman, Christopher P Reinhardt: Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products. BioPhysics Assay Laboratory, Lawson & Weitzen, Sonia K Guterman, May 23, 2006: US07048907 (21 worldwide citation)

Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotopes as a chemical bar code for vial ...


8
John F Ranta, Walter A Aviles, R Bruce Donoff, Linda P Nelson: Methods and apparatus for simulating dental procedures and for training dental students. President and Fellows of Harvard College, Sonia K Guterman, Adam M Schoen, Lawson & Weitzen, July 31, 2007: US07249952 (18 worldwide citation)

A training system using haptically enhanced simulations of dental procedures to provide the sensorimotor involvement needed for dental training. To provide touch feedback in combination with a realistic visual experience, the system integrates a haptic stylus interface for simulating the movement an ...


9
Thomas Blake, Zheng Ouyang, Robert G Cooks: System and method for preparative mass spectrometry. Purdue Research Foundation, Lawson & Weitzen, Sonia K Guterman, Adam M Schoen, June 3, 2008: US07381373 (11 worldwide citation)

A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates t ...


10
Lawrence A Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul, Sebastian Kossek, Gary W Pace: Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors. Protiveris, Sonia K Guterman, Lawson & Weitzen, November 28, 2006: US07141385 (7 worldwide citation)

An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the ...



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