1
Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Closed-loop biochemical analyzers. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, May 22, 2001: US06235471 (227 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


2
Colin Kennedy: Fabrication of microfluidic circuits by printing techniques. Caliper Technologies, Mathew B Murphy, Jonathan Alan The Law Offices of Jonathan Alan Quine Quine, June 13, 2000: US06074725 (226 worldwide citation)

Laminates having microfluidic structures disposed between sheets of the laminate are provided. The microfluidic structures are raised on a sheet of laminate, typically by printing the structure on the sheet. Printing methods include Serigraph, ink-jet, intaligo, offset printing and thermal laser pri ...


3
Robert S Dubrow, Colin B Kennedy, Luc J Bousse: Microfluidic devices incorporating improved channel geometries. Caliper Technologies, Matthew B Murphy, Jonathan Alan The Law Offices of Jonathan Alan Quine Quine, May 30, 2000: US06068752 (205 worldwide citation)

The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through t ...


4
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, July 31, 2001: US06267858 (182 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


5
Andreas Crameri, Willem P C Stemmer, Jeremy Minshull, Steven H Bass, Mark Welch, Jon E Ness, Claes Gustafsson, Phillip A Patten: Oligonucleotide mediated nucleic acid recombination. Maxygen, Norman J Kruse, Jonathan Alan Quine, Law Offices of Jonathan Alan Quine, April 23, 2002: US06376246 (180 worldwide citation)

Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.


6
John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies, Matthew B Murphy, Stacy Landry, Law Offices of Jonathan Alan Quine, May 29, 2001: US06238538 (170 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...


7
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies, Gulshan H Shaver, Jonathan Alan Quine, Law Offices of Jonathan Alan Quine, August 14, 2001: US06274337 (165 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


8
John M Butler, Jia Li, Joseph A Monforte, Christopher H Becker: DNA typing by mass spectrometry with polymorphic DNA repeat markers. Genetrace Systems, Law Offices of Jonathan Alan Quine, July 18, 2000: US06090558 (139 worldwide citation)

The present invention is related to the fields of genetic mapping and genetic identity detection, including forensic identification and paternity testing. This invention is more specifically directed to the use of mass spectrometry to detect length variation in DNA nucleotide sequence repeats (inclu ...


9
Anne R Kopf Sill: Inefficient fast PCR. Caliper Technologies, Matthew B Murphy, Jonathan Alan Quine, Law Offices of Jonathan Alan Quine, October 16, 2001: US06303343 (124 worldwide citation)

Methods of performing fast polymerase mediated reactions are provided. These reactions can be used in an inefficient fashion in the cycles of the polymerase mediated reactions to produce product at a much faster rate than conventional polymerase mediated reaction methods. Integrated systems for perf ...


10
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, October 23, 2001: US06306659 (120 worldwide citation)

An apparatus for analyzing a plurality of compounds is used in conjunction with microfluidic devices for performing high throughput screening assays. A conveyor system delivers libraries of compounds to a microfluidic device which accesses the compounds in order to screen large numbers of different ...