1
Glenn H McGall, Stephen P A Fodor, Edward L Sheldon: Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces. Affymax Technologies, Lauren L Stevens, May 2, 1995: US05412087 (338 worldwide citation)

Substrates with surfaces comprising compounds with thiol functional groups protected with a photoremovable protecting group can be used to construct arrays of immobilized anti-ligands, such as oligonucleotide probes or other biological polymers. The arrays can be used in assays to detect the presenc ...


2
William J Dower, Ronald W Barrett, Mark A Gallop, Michael C Needels: Synthesizing and screening molecular diversity. Affymax Technologies, Kevin Kaster, Vern Norviel, Lauren L Stevens, June 17, 1997: US05639603 (289 worldwide citation)

A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.


3
Christopher P Holmes: Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof. AFFYMAX Technologies, Lauren L Stevens, August 27, 1996: US05549974 (203 worldwide citation)

The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general me ...


4
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Lauren L Stevens, September 19, 1995: US05451683 (185 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


5
William J Dower, Gregory L Heinkel, Larry Mattheakis, Peter J Schatz: Use of modified tethers in screening compound libraries. Glaxo Group, Joe Liebeschuetz, Lauren L Stevens, September 28, 1999: US05958703 (161 worldwide citation)

The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis ...


6
Mark A Gallop, Martin A Murphy: Methods for synthesizing diverse collections of pyrrolidine compounds. AFFYMAX Technologies, Lauren L Stevens, June 11, 1996: US05525735 (160 worldwide citation)

Disclosed are methods for synthesizing very large collections of diverse pyrrolidine compounds and derivatives thereof on solid supports and synthetic compound libraries comprising pyrrolidine groups and derivatives thereof prepared by such methods.


7
Ron L Hale, Amy Lu, Dennis Solas, Harold E Selick, Kevin R Oldenburg, Alejandro C Zaffaroni: Compositions and methods for enhanced drug delivery. Affymax Technologies, Lauren L Stevens, March 4, 1997: US05607691 (158 worldwide citation)

The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and de ...


8
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Kevin R Kaster, Tracy J Dunn, Lauren L Stevens, January 9, 1996: US05482867 (150 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


9
Christopher P Holmes: Polymer reversal on solid surfaces. Affymax Technologies, Kevin R Kaster, Vernon A Norviel, Lauren L Stevens, September 7, 1993: US05242974 (149 worldwide citation)

A method for cyclization and reversal of the polarity of polymers on a substrate. The method provides for the formation of a polymer on a substrate (2) with a tether molecule (4). Through unmasking of a protective group (PG.sub.2) a cyclic polymer (6) is formed. Through cleavage of an appropriate bo ...


10
William J Dower, Ronald W Barrett, Mark A Gallop, Michael C Needels: Tagged synthetic oligomer libraries. Affymax Technologies, Lauren L Stevens, Kevin R Kaster, June 23, 1998: US05770358 (143 worldwide citation)

A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.