1
Malcolm J Simons: Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes. GeneType, Laura Terlizzi, March 9, 1993: US05192659 (307 worldwide citation)

The present invention provides a method for detection of at least one allele of a genetic locus and can be used to provide direct determination of the haplotype. The method comprises amplifying genomic DNA with a primer pair that spans an intron sequence and defines a DNA sequence in genetic linkage ...


2
Keith G Copeland, Thomas M Grogan, Charles Hassen, William R Humphreys, Charles D Lemme, Phillip C Miller, William L Richards, Wayne A Showalter: Automated biological reaction apparatus. Ventana Medical Systems, Laura Terlizzi, Philip J McKay, Skjerven Morrill MacPherson Franklin & Friel, January 21, 1997: US05595707 (206 worldwide citation)

An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of sli ...


3
Andrew G Hood III: Platelet glue wound sealant. Quantic Biomedical Partners, Laura Terlizzi, Skjerven Morrill MacPherson Franklin & Friel, March 31, 1998: US05733545 (138 worldwide citation)

A plasma-buffy coat concentrate that comprises plasma, platelets at a concentration of at least 1.0.times.10.sup.9 cells/ml, and fibrinogen at concentration of at least 5 mg/ml is described. The plasma-buffy coat concentrate can be combined with a fibrinogen activator to form a platelet glue wound s ...


4
Eric K Gustafson, John Lee, Yuh Geng Tsay: Highly reflective biogratings. Adeza Biomedical Corporation, Laura Terlizzi, Skjerven Morrill MacPherson Franklin & Friel, December 26, 1995: US05478527 (91 worldwide citation)

A reflective biograting consists of an optically flat layer of a transparent composition such as silicon dioxide having a first and second surface, alternating zones of active and inactive binding reagent on the first surface, and a reflective metal layer having a thickness of at least above 1000 .A ...


5
Bennie J Walthall, Yvonne E McHugh, Houston F Voss: Transplantable artificial tissue. Hana Biologics, William B Walker, Laura Terlizzi, February 20, 1990: US04902295 (91 worldwide citation)

A transplantable artificial tissue matrix structure containing viable cells which is suitable for insertion into the body is made by polymerizing precursors in an aqueous solution to form a shape retaining solid matrix comprising viable cells, matrix polymer and reversible gel polymer. The solution ...


6
Malcolm J Simons: Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes. GeneType, Laura Terlizzi, Skjerven Morrill MacPherson Franklin & Friel, March 18, 1997: US05612179 (89 worldwide citation)

The present invention provides a method for detection of at least one allele of a genetic locus and can be used to provide direct determination of the haplotype. The method comprises amplifying genomic DNA with a primer pair that spans an intron sequence and defines a DNA sequence in genetic linkage ...


7
James A Wells, Brian C Cunningham: Method for identifying active domains and amino acid residues in polypeptides and hormone variants. Genetech, Laura Terlizzi, Emily M Haliday, Skjerven Morrill MacPherson Franklin & Friel, December 3, 1996: US05580723 (87 worldwide citation)

The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting selected amino acid segments of the polyp ...


8
Barbara D Boss, Dennis H Spector: Proliferated neuron progenitor cell product and process. Somatix Therapy Corporation, Laura Terlizzi, Skjerven Morrill MacPherson Franklin & Friel, May 2, 1995: US05411883 (86 worldwide citation)

This invention is based on the development of procedures for isolation and proliferation of neuron progenitor cells and is directed to growth, storage, production and implantation of proliferated neuron progenitor cells. The isolation and culture methods are designed to proliferate mammalian ventral ...


9
Brian C Cunningham, Henry Lowman, James A Wells: Human growth hormone variants having greater affinity for human growth hormone receptor at site 1. Genentech, Laura Terlizzi, Emily M Haliday, Skjerven Morrill MacPherson Franklin & Friel, July 9, 1996: US05534617 (84 worldwide citation)

Human growth hormone variants are disclosed wherein the lysine at position 41 and/or the leucine at position 45 of native human growth hormone, numbered from the mature N-terminus of native human growth hormone, has been replaced with another amino acid. Also claimed are combination variants that ha ...


10
Andrew G Hood III: Wound sealant preparation and application device and method. Quantic Biomedical Partners, Laura Terlizzi, Bradford P Schmidt, Skjerven Morrill MacPherson Franklin & Friel, March 30, 1999: US05887755 (78 worldwide citation)

The present invention provides a preparation and application device useful for mixing and dispensing a plurality of fluids, wherein the fluids must be mixed immediately prior to use. In one embodiment, the device includes two fluid delivery systems connected to a manifold having two separate fluid c ...