1
Torben Lorentzen: Electrosurgical instrument for tissue ablation, an apparatus, and a method for providing a lesion in damaged and diseased tissue from a mammal. Klein & Szekeres, September 14, 1999: US05951546 (391 worldwide citation)

An electrosurgical instrument, an apparatus employing such instrument, and a method for using such instrument and apparatus for tissue ablation, are useful for forming lesions in tissue, whereby tumors, birth marks, or the like may be removed. The electrosurgical instrument has an elongated tubular ...


2
Andrew H Cragg, Rodney Brenneman: Percutaneous hemostasis device. Sub Q, Klein & Szekeres, July 21, 1998: US05782861 (310 worldwide citation)

A vascular hemostasis device comprises a shaft coaxially received within a hollow tube, and having a distal end formed with an opposed pair of resilient grasping prongs. The tube has an open distal end that may be situated percutaneously adjacent a vascular puncture site. The shaft and the tube are ...


3
Rodney Brenneman, Andrew H Cragg: Apparatus and method for percutaneous sealing of blood vessel punctures. Sub Q, Klein & Szekeres, July 8, 1997: US05645566 (265 worldwide citation)

A device for promoting hemostasis in a blood vessel puncture is employed with an introducer that accesses the puncture through an incision. The introducer has an open distal end positionable at the puncture, an external portion with an open proximal end, and an axial channel therebetween. The device ...


4
Carlos M G Duran, David T Cheung, David C Pang: Compliant dehydrated tissue for implantation and process of making the same. The International Heart Institute of Montana Foundation, Gabor L Szekeres, Klein & Szekeres, August 21, 2001: US06277555 (251 worldwide citation)

A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until ...


5
Carlos M G Duran, David T Cheung, David C Pang: Solution and method for treating autologous tissue for implant operation. The International Heart Institute of Montana Foundation, Klein & Szekeres, March 5, 2002: US06352708 (250 worldwide citation)

An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host mammal and to render the tissue temporarily more rigid than in its native state, and better suited for shapi ...


6
Rodney A Brenneman, Jay A Lenker: Resorbable urethral stent and apparatus for its insertion. Advanced Surgical Intervention, Klein & Szekeres, November 3, 1992: US05160341 (239 worldwide citation)

A resorbable stent, particularly adapted for implantation in the penile urethra, comprises a helical coil formed from a filament of a biocompatible, biodegradable material that is resiliently deformable. The stent is compressible from a first diameter to a smaller second diameter, and restores itsel ...


7
Robert F Rosenbluth, Rodney A Brenneman: Apparatus and method for laparaoscopic ligation. Advanced Surgical Intervention, Klein & Szekeres, May 17, 1994: US05312423 (197 worldwide citation)

A laparoscopic ligation device comprises an elongate hollow tube, having an open distal end. An arcuate finger, attached to the tube, has a tip that is distally spaced from the distal end of the tube. The finger includes structure adjacent its tip that releasably holds the tag end of a length of sut ...


8
Rich B Meyer Jr, Alexander A Gall, Michael W Reed: Peptide linkers for improved oligonucleotide delivery. MicroProbe Corporation, Klein & Szekeres, November 12, 1996: US05574142 (194 worldwide citation)

A covalently linked conjugate of an oligonucleotide (ODN) with a peptide and a carrier or targeting ligand (ODN-peptide-carrier) includes a therapeutic oligonucleotide which is capable of selectively binding to a target sequence of DNA, RNA or protein inside a target cell. The ODN is covalently link ...


9
Treesa A Spencer: Disposable hypodermic syringe and needle combination having retractable, accident preventing sheath. Klein & Szekeres, October 27, 1987: US04702738 (191 worldwide citation)

A disposable combination of a hypodermic syringe and needle has a sheath movably mounted on the syringe barrel to normally occupy a first position wherein the sheath extends to cover and protect the needle. Substantially axial guide channels are provided in the exterior surface of the barrel to acce ...


10
Carlos M G Duran: Atrio-ventricular valvular device. The International Heart Institute of Montana Foundation, Klein & Szekeres, March 19, 2002: US06358277 (170 worldwide citation)

An anatomically designed atrioventricular valve is made of biologically compatible synthetic membrane or biological membrane of autologous, homologous or heterologous origin. A single piece of the selected membrane material is trimmed so as to form two unequal sheaths similar to the normal anterior ...