1
Bettina Strack Logue, Frank DeRosa, Michael Heartlein: Modification of RNA-related enzymes for enhanced production. Translate Bio, Proskauer Rose, Fangli Chen, Kimberly A Reynolds, December 4, 2018: US10144942

The present invention provides, among other things, methods and compositions for large-scale production of capped mRNA using SUMO-Guanylyl Transferase fusion protein.


2
Frank DeRosa, Michael Heartlein: MRNA therapy for pompe disease. Translate Bio, Proskauer Rose, Fangli Chen, Kimberly A Reynolds, January 8, 2019: US10172924

The present invention provides, among other things, methods of treating Pompe disease, including administering to a subject in need of treatment a composition comprising an mRNA encoding acid alpha-glucosidase (GAA) at an effective dose and an administration interval such that at least one symptom o ...


3
Daniel Roseman: Characterization of lysosomal enzymes by capillary zone electrophoresis. Shire Human Genetic Therapies, Proskauer Rose, Fangli Chen, Kimberly A Reynolds, July 17, 2018: US10023901

The present invention provides, among other things, methods for the characterization of recombinant Heparan N-Sulfatase (HNS) during manufacture. The present invention uses capillary zone electrophoresis to determine the charge profile, isoform distribution, and/or glycan profile of recombinant HNS; ...