1
Helen C Loughrey, Pieter R Cullis, Marcel B Bally, Lewis S Choi: Method for protein-liposome coupling. The Liposome Company, Kenneth B Rubin, March 21, 1995: US05399331 (83 worldwide citation)

This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated ...


2
Paul Edward Aldrich, Argyrios Georgios Arvanitis, Robert Scott Cheeseman, Robert John Chorvat, Thomas Eugene Christos, Paul Joseph Gilligan, Dimitri Emil Grigoriadis, Carl Nicholas Hodge, Paul John Krenitsky, Everett Latham Scholfield, Sang William Tam, Zelda Rakowitz Wasserman: 1N-alkyl-n-arylpyrimidinamines and derivatives thereof. DuPont Pharmaceuticals Company, Robert W Black, Kenneth B Rubin, Kalim S Fuzail, January 29, 2002: US06342503 (66 worldwide citation)

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppressi ...


3
Robert P Lenk, Anthony G Durning, Robert J Klimchak, Joel Portnoff, Michelle L Tomsho: Method for size separation of particles. The Liposome Company, Kenneth B Rubin, Rosanne Goodman, September 7, 1999: US05948441 (65 worldwide citation)

Tangential flow filtration is used in the size separation of particles, such as liposomes and lipid particles. These particles may be passed through a tangential flow filtration device of any pore size desired. Tangential flow filter systems of various pore sizes may be used sequentially to obtain p ...


4
Marcel B Bally, Pieter R Cullis, Michael J Hope, Thomas D Madden, Lawrence D Mayer: Encapsulation of antineoplastic agents in liposomes. The Liposome Company, Kenneth B Rubin, April 7, 1998: US05736155 (61 worldwide citation)

Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplast ...


5
Paul Edward Aldrich, Argyrios Georgios Arvanitis, Rajagopal Bakthavatchalam, James Peter Beck, Robert Scott Cheeseman, Robert John Chorvat, Paul Joseph Gilligan, Carl Nicholas Hodge, Zelda Rakowitz Wasserman: 1N-alkyl-N-arylpyrimidinamines and derivatives thereof. Dupont Pharmaceuticals Company, Monte R Browder, Kenneth B Rubin, August 22, 2000: US06107301 (58 worldwide citation)

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppressi ...


6
Austin L Bailey, Pieter R Cullis: Fusogenic lipsomes and methods for making and using same. The Liposome Company, Kenneth B Rubin, September 3, 1996: US05552155 (52 worldwide citation)

A liposome composition is provided which contains a liposome having: (i) an outermost lipid bilayer containing, in addition to a neutral, bilayer preferring lipid, a fusion-promoting effective amount of an ionizable lipid having a protonatable, cationic headgroup and an unsaturated acyl chain; and ( ...


7
Lawrence D Mayer, Marcel B Bally, Pieter R Cullis, Richard S Ginsberg, George N Mitilenes: Liposomal antineoplastic agent compositions. The Liposome Company, Rosanne Goodman, Kenneth B Rubin, August 18, 1998: US05795589 (46 worldwide citation)

A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a tranamembrane pH gradient. Using this technique, tra ...


8
Mircea C Popescu, Alan L Weiner, Marie S Recine, Andrew S Janoff, Leonard Estis, Lynn D Keyes, Carl R Alving: Potentiation of immune responses with liposomal adjuvants. The Liposome Company, Kenneth B Rubin, Rosanne Goodman, July 18, 2000: US06090406 (40 worldwide citation)

A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a lipo ...


9
Yong Wei, Eric Mayhew, Imran Ahmad, Andrew S Janoff: Pharmaceutically active ceramide-related compounds. The Liposome Company, Kenneth B Rubin, May 20, 1997: US05631394 (35 worldwide citation)

This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --C ...


10
Andrew S Janoff, Pieter R Cullis, Marcel B Bally, Michael W Fountain, Richard S Ginsberg, Michael J Hope, Thomas D Madden, Hugh P Schieren, Regina L Jablonski: Methods of dehydrating, storing and rehydrating liposomes. The Liposome Company, Kenneth B Rubin, Rosanne Goodman, July 13, 1999: US05922350 (33 worldwide citation)

Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. F ...



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