1
Thomas Genetta: Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors. The Children s Hospital of Philadelphia, Dann Dorfman Herrell and Skillman, Kathleen D Rigaut, July 18, 2006: US07078180 (59 worldwide citation)

Methods, compositions and kits which employ one or more ZEB specific detection reagents for detection and localization of ZEB associated molecules in tumor cells are disclosed. Also provided are methods for determining stage and progression of cancer in a mammal based on alterations in ZEB expressio ...


2
Donald L Durden: Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways. Indiana University Research and Technology Corporation, Dann Dorfman Herrell & Skillman, Kathleen D Rigaut, June 29, 2010: US07745485 (47 worldwide citation)

Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.


3
Donald L Durden: Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways. Indiana University Research and Technology Corporation, Dann Dorfman Herrell & Skillman, Kathleen D Rigaut, December 30, 2008: US07470721 (47 worldwide citation)

Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.


4
Ulf Hans Eskil Soderlind, Carl Arne Krister Borrebaeck: Method for in vitro molecular evolution of protein function. Bioinvent International, Dann Dorfman Herrell and Skillman, Kathleen D Rigaut, January 24, 2006: US06989250 (22 worldwide citation)

The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired characteristics can be obtained by in ...


5
Daniel Bozinov, Jörg Rahnenführer: Cluster analysis of genetic microarray images. The Board of Regents of the University of Nebraska, Dann Dorfman Herrell and Skillman, Kathleen D Rigaut, April 18, 2006: US07031844 (16 worldwide citation)

A method for determining relative incidence of a binding substance within two biological samples is provided. The two samples are labeled with luminescent materials having different chromatic properties. An image of the luminescent materials upon a binding site of a microarray is analyzed as two clu ...


6

7

8
Stephan A Grupp, Valerie I Brown: Methods for treatment of acute lymphocytic leukemia. The Children s Hospital of Philadelphia, Dann Dorfman Herrell and Skillman, Kathleen D Rigaut, April 11, 2006: US07026330 (8 worldwide citation)

Methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin or a derivative thereof are provided. Also provided are methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin or a derivative thereof in combina ...


9
Larry J Smith: Method and compositions for cellular reprogramming. Larry J Smith, Dann Dorfman Herrell & Skillman, Kathleen D Rigaut, April 14, 2009: US07517644 (8 worldwide citation)

The present invention provides methods and compositions useful in treating certain diseases herein termed “Aberrant Programming Diseases,” including cancer and AIDS. According to one aspect of the invention, there is provided a method for treating an individual having an Aberrant Programming disease ...


10