1
Ronald T Kurnik, Janet Tamada, Michael Tierney: Chemical signal-impermeable mask. Cygnus, Karl Bozicevic & Reed Bozicevic, April 7, 1998: US05735273 (304 worldwide citation)

A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents s ...


2
Eric T Johansson, Carl Ritson, Reid M Rubsamen: Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, May 26, 1998: US05755218 (164 worldwide citation)

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identific ...


3
Reid M Rubsamen: Intrapulmonary delivery of hematopoietic drug. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, January 11, 2000: US06012450 (145 worldwide citation)

A method of treating human patients is provided by the intrapulmonary delivery of a formulation containing a hematopoietic drug. The formulation is automatically released in an aerosolized form from a hand-held, self-contained, portable device comprised of a means for automatically releasing a measu ...


4
Lester John Lloyd, Peter M Lloyd, Reid M Rubsamen: Intrapulmonary delivery of aerosolized formulations. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, January 20, 1998: US05709202 (115 worldwide citation)

Liquid, flowable formulations including aqueous formulations of a pharmaceutically active drug are packaged in individual dosage unit containers which containers are interconnected to form a cellular array designed to be integrated into a dispensing device capable of individually opening dosage unit ...


5
Igor Gonda, Reid M Rubsamen, Stephen J Farr: Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, March 23, 1999: US05884620 (93 worldwide citation)

Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for de ...


6
David E Goodman, Reid M Rubsamen: Delivery of aerosol medications for inspiration. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, October 27, 1998: US05826570 (81 worldwide citation)

Apparatus and methods for delivering an amount of aerosolized medicine for inspiration by a patient in response to the occurrence of appropriate delivery point or points in the patient's detected breath flow. The aerosol medication may be administered as one or more pulses having a pulse width, shap ...


7
Reid M Rubsamen, Eric T Johansson: Method for releasing controlled amount of aerosol medication. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, April 28, 1998: US05743252 (79 worldwide citation)

A method for releasing a controlled amount of aerosol medication is disclosed. The method of the invention is preferably used in connection with a portable, battery-powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient. The inhalation breath flow ...


8
Igor Gonda, Reid M Rubsamen, Stephen J Farr: Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, March 30, 1999: US05888477 (67 worldwide citation)

The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of monomeric insulin and/or an inhale-exhale br ...


9
Stanley B Prusiner, Kivotoshi Kaneko, Fred E Cohen: Formation and use of prion protein (PRP) complexes. The Regents of the University of California, Karl Bozicevic & Reed Bozicevic, May 12, 1998: US05750361 (56 worldwide citation)

Prion protein (PrP) peptides having at least one .alpha.-helical domain and forming a random coil conformation in aqueous solutions bind cellular PrP (PrP.sup.C) to form a complex having characteristics of the scrapie isoform (PrP.sup.Sc). Methods for screening compounds able to inhibit or decrease ...


10
Stephen J Ruskewicz: Aerosol extrusion mechanism. Aradigm Corporation, Karl Bozicevic & Reed Bozicevic, January 5, 1999: US05855564 (46 worldwide citation)

Devices for the generation of inhalable aerosols by extrusion through a porous membrane by a motor-driven cam assembly are disclosed. The device holds a drug formulation container in a drug release position. The package is comprised of a collapsible wall with an opening and a cover for the opening t ...