1
Thomas Harry Barrows: Bioabsorbable triglycolic acid poly(ester-amide)s. BioAmide, Grady J Frenchick, Karen B King, Michael Best & Friedrich, September 19, 2000: US06120788 (153 worldwide citation)

This invention relates to fiber-forming bioabsorbable poly(ester-amide)s made by the polymerization of diamidediols with 3,6-dioxaoctanedioic acid, also known as "triglycolic acid". More specifically it relates to diol terminated poly(ester-amide)s of triglycolic acid that are optionally further rea ...


2
Craig E Smith, Charles K York: Methods of isolating biological target materials using silica magnetic particles. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, February 22, 2000: US06027945 (97 worldwide citation)

The present invention provides methods for isolating biological target materials, particularly nucleic acids, such as DNA or RNA or hybrid molecules of DNA and RNA, from other substances in a medium using silica magnetic particles. The methods of the present invention involve forming a complex of th ...


3
James W Schumm, Cynthia J Sprecher, Ann M Lins: Multiplex amplification of short tandem repeat loci. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, April 24, 2001: US06221598 (89 worldwide citation)

The present invention is directed to the simultaneous amplification of multiple distinct genetic loci using PCR or other amplification systems to determine in one reaction the alleles of each locus contained within the multiplex.


4
James W Schumm, Katherine A Micka, Dawn R Rabbach: Multiplex amplification of short tandem repeat loci. Promega Corporation, Grady J Stroud Stroud Willink Thompson & Howard Frenchick, Karen B King, December 1, 1998: US05843660 (70 worldwide citation)

The present invention is directed to the simultaneous amplification of multiple distinct genetic loci using PCR or other amplification systems to determine in one reaction the alleles of each of the loci contained within the multiplex.


5
Jack D Bankier, Philip M Cashmer: System for analyzing a substance from a solution following filtering of the substance from the solution. Promega Corporation, Grady J Stroud Stroud Willink Thompson & Howard Frenchick, Karen B King, December 8, 1998: US05846493 (65 worldwide citation)

A system is provided for filtering a substance from a solution for subsequent analysis of the substance. The system has a manifold and a removable cover capable of latching onto a base defining an interior of the manifold. Apertures are formed in the cover capable of receiving columns having a filte ...


6
Steven J Ekenberg: Method of isolating RNA. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, April 17, 2001: US06218531 (62 worldwide citation)

The present invention provides a method for isolating RNA from a biological material comprising RNA and contaminants, wherein: the biological material is disrupted in the presence of a chaotropic agent, the resulting lysate is diluted to precipitate out contaminants, and the precipitate is removed f ...


7
Craig E Smith, Diana L Holmes, Daniel J Simpson, Jehoshua Katzenhendler, Rex M Bitner, Josephine C Grosch: pH dependent ion exchange matrix and method of use in the isolation of nucleic acids. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, October 30, 2001: US06310199 (51 worldwide citation)

pH dependent ion exchange matrices are provided, with methods for making such matrices, and methods for using such matrices to isolate a target nucleic acid, such as plasmid DNA, chromosomal DNA, or RNA from contaminants, including proteins, lipids, cellular debris, or other nucleic acids. Each pH d ...


8
Rex M Bitner, Craig E Smith, Douglas H White, Braeden L Butler, Jacqui Sankbeil: Kits for cell concentration and lysate clearance using paramagnetic particles. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, September 4, 2001: US06284470 (42 worldwide citation)

Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of cells or a homogenate of mammalian tissue. Methods are also disclosed for using paramagnetic particles to i ...


9
James W Schumm, Cynthia J Sprecher: Multiplex amplification of short tandem repeat loci. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, November 12, 2002: US06479235 (33 worldwide citation)

Methods and materials are disclosed for use in simultaneously amplifying at least thirteen loci of genomic DNA in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and methods for the s ...


10
Craig E Smith, Donald A Creswell, Rex M Bitner, Douglas H White, Braeden L Butler, Scott A Lesley: Endotoxin reduction in nucleic acid purification. Promega Corporation, Grady J Frenchick, Karen B King, Michael Best & Friedrich, February 27, 2001: US06194562 (28 worldwide citation)

The present invention presents a novel method for removing endotoxins from nucleic acids, such as DNA, RNA, or hybrids thereof, contaminated therewith. Nucleic acid solutions which can be treated using the method of this invention include, but are not limited to, lysates of gram-negative bacteria an ...