1
James Aggen, John H Griffin, Mathai Mammen, Daniel Marquess, Edmund J Moran, David Oare: Muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Joyce G Cohen, February 17, 2004: US06693202 (123 worldwide citation)

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modu ...


2
Seok Ki Choi, Edmund J Moran: &bgr;2-adrenergic receptor agonists. Theravance, Jeffrey A Hagenah, Roberta P Saxon, Joyce G Cohen, July 15, 2003: US06593497 (27 worldwide citation)

The present invention is directed to multibinding compounds which are &bgr;2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and prematu ...


3
Edmund J Moran, Seok Ki Choi: &bgr;2-adrenergic receptor agonists. Theravance, Roberta P Saxon, Jeffrey A Hagenah, Joyce G Cohen, March 30, 2004: US06713651 (24 worldwide citation)

Disclosed are multibinding compounds which are &bgr;2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


4

5
Martin S Linsell, J Kevin Judice: Polyacid glycopeptide derivatives. Theravance, Jeffrey A Hagenah, Roberta P Saxon, Joyce G Cohen, August 3, 2004: US06770621 (10 worldwide citation)

Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO


6
Edmund J Moran, Seok Ki Choi: β2-adrenergic receptor agonists. Theravance, Joyce G Cohen, Roberta P Saxon, Jeffrey A Hagenah, July 19, 2005: US06919482 (7 worldwide citation)

Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


7
Edmund J Moran, Seok Ki Choi: &bgr;2-adrenergic receptor agonists. Theravance, Roberta P Saxon, Jeffrey A Hagenah, Joyce G Cohen, January 27, 2004: US06683115 (6 worldwide citation)

Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


8
Donald E Schmidt, Jeanmarie Donovan Sganga: Process for purifying glycopeptide phosphonate derivatives. Theravance, Jeffrey A Hagenah, Roberta P Saxon, Joyce G Cohen, March 21, 2006: US07015307 (6 worldwide citation)

Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, elu ...


9
Yu Hua Ji, Maya Natarajan, John H Griffin, Thomas E Jenkins: Calcium channel drugs and uses. Theravance, Jeffrey A Hagenah, Roberta P Saxon, Joyce G Cohen, May 24, 2005: US06897305 (3 worldwide citation)

Novel multibinding compounds are disclosed. The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel , thereby modulating the biological activities thereof.


10
Seok Ki Choi, Paul R Fatheree, David C Green, Daniel Marquess: Sodium channel modulators. Theravance, Jeffrey A Hagenah, Roberta P Saxon, Joyce G Cohen, March 29, 2005: US06872741 (3 worldwide citation)

The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therap ...



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