1
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-Fluoronucleosides. Emory University, University of Georgia Research Foundation, Sherry M Knowles Esq, Josephine Young, King & Spalding, February 19, 2002: US06348587 (115 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:


2
Gilles Gosselin, Jean Louis Imbach, Martin L Bryant: &bgr;-L-2′-deoxy-nucleosides for the treatment of hepatitis B. Novirio Pharmaceuticals, Centre National da la Recherche Scientifique, Sherry M Knowles Esq, Josephine Young, King & Spalding, May 28, 2002: US06395716 (46 worldwide citation)

This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′-deoxy-&bgr;-L-e ...


3
Gilles Gosselin, Jean Louis Imbach, Martin L Bryant: &bgr;-L-2'-deoxy-nucleosides for the treatment of hepatitis B. Novirio Pharmaceuticals, Centre National da la Recherche Scientifique, Sherry M Knowles Esq, Josephine Young, King & Spalding, September 3, 2002: US06444652 (43 worldwide citation)

This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′-deoxy-&bgr;-L-e ...


4
Gilles Gosselin, Jean Louis Imbach, Jean Pierre Sommadossi, Raymond F Schinazi: &bgr;-L nucleosides for the treatment of HIV infection. Emory University, Centre National de la Recherche Scientifique, The UAB Research Foundation, Sherry M Knowles Esq, Josephine Young, King & Spalding, June 18, 2002: US06407077 (10 worldwide citation)

Compounds and pharmaceutical compositions active against HIV are provided, as is a method for the treatment of HIV infection in humans and other host animals is provided comprising administering an effective amount of a &bgr;-L-(2′ or 3′-azido)-2′,3′-dideoxy-5-fluorocytosine of the formula