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Edwin Bernard Villhauer: N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, December 26, 2000: US06166063 (137 worldwide citation)

The present invention relates to a compound of formula (I) ##STR1## wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in in ...


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Edwin Bernard Villhauer: N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, January 4, 2000: US06011155 (125 worldwide citation)

N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-depend ...


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Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider: Benzofuranone or indolinone compounds useful as stabilizers for organic materials. Sandoz, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, April 20, 1982: US04325863 (115 worldwide citation)

The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran (2) one or indolin (2) one compound as stabilizer. Such stabilized polymeric materials are stabilized against degradation during the polymer processing.


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Hans Hinsken, Horst Mayerhoefer, Wolfgang Mueller, Hermann Schneider: Benzofuran(2)one or indolin(2)one compounds useful as stabilizers for organic materials. Sandoz, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, July 6, 1982: US04338244 (104 worldwide citation)

The present invention relates to a process for stabilizing organic polymeric materials comprising incorporating therein a benzofuran(2)one compound or indolin(2)one compound containing at least two benzofuran(2)one or indolin(2)one nuclei.


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Edwin Bernard Villhauer: N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, August 29, 2000: US06110949 (89 worldwide citation)

The invention discloses certain N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing said compounds as an active ingredient thereof, and the use of said compounds in inhibiting dipeptidyl peptidase-IV.


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Edwin Bernard Villhauer: Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, September 26, 2000: US06124305 (69 worldwide citation)

N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## wherein R is as defined herein. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DP ...


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Moise Azria, Karl Heinz Buchheit, Keith A Dixon, G unther Engel, Rudolf K A Giger: Use of certain imidazol carbazols in treating stress-related manic-depressive disorders. Sandoz, Robert S Honor, Melvyn M Kassenoff, Joseph J Borovian, October 1, 1996: US05561149 (66 worldwide citation)

Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufaccure of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorde ...


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Assunta Imperato, Dietmar Romer: New use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents. Sandoz, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, August 13, 1991: US05039680 (65 worldwide citation)

The invention provides use of a 5HT-3 antagonist in the manufacture of a medicament suitable for the prevention or reduction of dependence on a dependence-inducing agent.