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Christopher R Young, Charles William Rowe: Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide. Vertex Pharmaceuticals Incorporated, Honigman Miller, Jonathan P O Brien, June 30, 2009: US07553855 (76 worldwide citation)

Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein.


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Sara S Hadida Ruah, Peter D J Grootenhuis, Fredrick Van Goor, Jinglan Zhou, Brian Bear, Mark T Miller, Jason McCartney, Mehdi Michel Djamel Numa: Indole derivatives as CFTR modulators. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Jonathan P O Brien, January 12, 2010: US07645789 (74 worldwide citation)

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods o ...


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Sara S Hadida Ruah, Peter D J Grootenhuis, Frederick Van Goor, Jinglan Zhou, Brian Bear, Mark T Miller, Jason McCartney, Mehdi Michel Jamel Numa, Xiaoqing Yang: Modulators of ATP-binding cassette transporters. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Jonathan P O Brien, Heidi M Berven, August 17, 2010: US07776905 (66 worldwide citation)

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods o ...


4
Christopher R Young, Charles William Rowe: Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, December 13, 2011: US08076357 (52 worldwide citation)

Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein.


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Sara Hadida Ruah, Anna Hazlewood, Peter D J Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney: Modulators of ATP-binding cassette transporters. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, January 24, 2012: US08101767 (50 worldwide citation)

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediate ...


7
Hayley Binch, Lev T D Fanning, Mehdi Michel Djamel Numa: Modulators of cystic fibrosis transmembrane conductance regulator. Vertex Pharmaceutical Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, November 20, 2012: US08314239 (44 worldwide citation)

The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.


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Sara Hadida Ruah, Anna Hazlewood, Peter D J Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney: Modulators of ATP-binding cassette transporters. Vertex Pharmaceutical Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, December 4, 2012: US08324242 (40 worldwide citation)

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediate ...


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Narendra Bhalchandra Ambhaikar, Robert Hughes, Dennis James Hurley, Elaine Chungmin Lee, Benjamin Littler, Mehdi Numa, Stefanie Roeper, Urvi Sheth: Process for preparing modulators of cystic fibrosis transmembrane conductance regulator. Vertex Pharmaceutical Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, January 1, 2013: US08344147 (40 worldwide citation)

The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-H ...


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Fredrick Van Goor: Modulators of ATP-binding cassette transporters. Vertex Pharmaceutical Incorporated, Honigman Miller Schwartz and Cohn, Christopher C Forbes, Jonathan P O Brien, January 15, 2013: US08354427 (37 worldwide citation)

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediate ...