1
John Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, August 24, 1999: US05942443 (559 worldwide citation)

Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.


2
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, April 4, 2000: US06046056 (443 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


3
John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, March 23, 1999: US05885470 (339 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...


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Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Closed-loop biochemical analyzers. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, May 22, 2001: US06235471 (233 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


6
Colin Kennedy: Fabrication of microfluidic circuits by printing techniques. Caliper Technologies, Mathew B Murphy, Jonathan Alan The Law Offices of Jonathan Alan Quine Quine, June 13, 2000: US06074725 (230 worldwide citation)

Laminates having microfluidic structures disposed between sheets of the laminate are provided. The microfluidic structures are raised on a sheet of laminate, typically by printing the structure on the sheet. Printing methods include Serigraph, ink-jet, intaligo, offset printing and thermal laser pri ...


7
Robert S Dubrow, Colin B Kennedy, Luc J Bousse: Microfluidic devices incorporating improved channel geometries. Caliper Technologies, Matthew B Murphy, Jonathan Alan The Law Offices of Jonathan Alan Quine Quine, May 30, 2000: US06068752 (210 worldwide citation)

The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through t ...


8
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, July 31, 2001: US06267858 (186 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


9
Andreas Crameri, Willem P C Stemmer, Jeremy Minshull, Steven H Bass, Mark Welch, Jon E Ness, Claes Gustafsson, Phillip A Patten: Oligonucleotide mediated nucleic acid recombination. Maxygen, Norman J Kruse, Jonathan Alan Quine, Law Offices of Jonathan Alan Quine, April 23, 2002: US06376246 (183 worldwide citation)

Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.


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John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies, Matthew B Murphy, Stacy Landry, Law Offices of Jonathan Alan Quine, May 29, 2001: US06238538 (170 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...