1
Giorgio Cirelli, Hans Steffen, Christian Surber: Portable injection appliance. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, A Kate Huffmann, December 12, 1989: US04886499 (441 worldwide citation)

The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emptying the vessel through t ...


2
Peter Loeliger: Stilbene derivatives. Hoffmann La Roche, Jon S Saxe, George M Gould, William H Epstein, April 20, 1982: US04326055 (175 worldwide citation)

This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.


3
Dieter Schmidt, Hans Steffen: Porphyrin derivatives as fluorescent markers for immunoassays. Hoffmann La Roche, Jon S Saxe, George M Gould, Patricia A Coburn, September 30, 1986: US04614723 (122 worldwide citation)

There are described novel porphyrin derivatives of the general formula ##STR1## wherein either R.sup.1 signifies the group ##STR2## and R.sup.2 signifies the group ##STR3## or R.sup.1 signifies the group ##STR4## and R.sup.2 signifies the group ##STR5## whereby X.sup.- signifies a halogen ion, an ar ...


4
Arthur Boller, Martin Schadt, Alois Villiger: Hydrogenated naphthalenes. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, William G Isgro, July 5, 1983: US04391731 (118 worldwide citation)

Compounds of the formula ##STR1## wherein ring A is saturated or aromatic and a saturated ring A which may be present is trans-linked with the second ring; R.sup.1 is a straight-chain alkyl or alkoxy group containing 1 to 11 carbon atoms; R.sup.2 is cyano, a straight-chain alkyl group containing 1 t ...


5
Sidney Pestka, Menachem Rubinstein: Protein purification process and product. Hoffmann La Roche, Jon S Saxe, George M Gould, Peter R Shearer, September 15, 1981: US04289690 (115 worldwide citation)

An improved process for purifying proteins, particularly proteins having molecular weights in excess of 12,000 involves novel applications of high performance liquid chromatography on a preparative scale to provide homogeneous end product in excellent yield. In an embodiment of the process, human in ...


6
Paul Hadvary, Erich Hochuli, Ernst Kupfer, Hans Lengsfeld, Ernst K Weibel: Leucine derivatives. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, George W Johnston, July 1, 1986: US04598089 (104 worldwide citation)

Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH.sub.2).sub.5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The inventive compounds can be produced by the cultivation of microorganis ...


7
Raphael J Mannino, Susan G Fogerite: Liposome methods and compositions. Jon S Saxe, Bernard S Leon, George M Gould, May 5, 1987: US04663161 (97 worldwide citation)

The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method ...


8
Prabhakar R Sheth, Jacques L Tossounian: Novel sustained release tablet formulations. Hoffmann La Roche, Jon S Saxe, George M Gould, R Hain Swope, September 11, 1979: US04167558 (95 worldwide citation)

A novel sustained release formulation for the preparation of tablets for oral administration is disclosed. The formulation is hydrodynamically balanced to be buoyant in gastric juice thereby remaining in the stomach for an extended period of time.


9
Edward J Lombardi Jr, Harold L Neuman, Alfred E Magro, Michael L Rishton: Percutaneous intra-aortic balloon apparatus. Kontron Cardiovascular, Jon S Saxe, Bernard S Leon, George W Johnston, December 7, 1982: US04362150 (85 worldwide citation)

Intra-aortic balloon apparatus is disclosed including a single chamber balloon sealably attached to the end of a catheter for non-surgical insertion into the aorta through the skin as by the standard Seldinger technique. In the preferred embodiment, the extreme end of the balloon is fixedly attached ...


10
Jurg Schrank, Hans Steffen: Pharmaceutical preparations. Hoffmann La Roche, Jon S Saxe, George M Gould, John J Maitner, October 25, 1983: US04411894 (82 worldwide citation)

Pharmaceutical compositions useful for the parenteral administration of fat-soluble medicaments are disclosed. The compositions comprise, in addition to the medicaments, a sugar-containing liposome solution or lyophilizates thereof.



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