1
John W Boretos, Robert A Poirier: Aortic heart valve catheter. The United States of America represented by the Department of Health Education and Welfare, John S Roberts Jr, Norman J Latker, Thomas G Ferris, November 8, 1977: US04056854 (660 worldwide citation)

An artificial valve remotely placeable in a blood vessel without major surgery to supplant the function of a malfunctioning natural valve including an expansible check valve remotely placed in a constricted configuration through the vessel and a remotely removable constraint for selective expansion ...


2
Josef Pitha: Pharmaceutical preparations containing cyclodextrin derivatives. The United States of America represented by the Department of Health and Human Services, John S Roberts Jr, February 23, 1988: US04727064 (268 worldwide citation)

The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the dr ...


3
Robert P Burruss: Noncombustion system for the utilization of tobacco and other smoking materials. John S Roberts Jr, February 27, 1979: US04141369 (190 worldwide citation)

An electrical device for the noncombustion utilization of tobacco and other smoking materials. The device consists of a canister or other appropriate container within which air is electrically heated to an appropriate temperature for volatilizing the desired components of smoking material previously ...


4
Peter M Howley, Nava Sarver, Ming Fan Law: Recombinant DNA process utilizing a papilloma virus DNA as a vector. The United States of America represented by the Department of Health and Human Services, John S Roberts Jr, December 6, 1983: US04419446 (174 worldwide citation)

A novel method and composition are provided for the replication and expression of exogenous genes in eukaryotic cells. A segment of a papilloma virus genome capable of extrachromosomal replication is linked to the foreign gene(s) using recombinant DNA techniques to provide a biologically functional ...


5
Robert C Gallo, Mikulas Popovic, Mangalasseril G Sarngadharan: Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions. The United States of America represented by the Secretary of the Department of Health and Human Services, John S Roberts Jr, May 28, 1985: US04520113 (159 worldwide citation)

This invention relates to the detection of antibodies in sera of AIDS and pre-AIDS patients and describes the biochemical and immunological analysis of antigens associated with the virus HTLV-III Human T-Cell Leukemia Virus. It is shown that antigens associated with the infection of human cells by t ...


6
Josef Pitha: Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives. The United States of America represented by the Secretary Dept of Health & Human Services, John S Roberts Jr, June 24, 1986: US04596795 (136 worldwide citation)

The administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed ...


7
Miguel F Refojo, Hsaio S Liu: Method for treating intraocular malignancies. The United States of America represented by the Secretary of the Department of Health and Human Services, John S Roberts Jr, November 17, 1981: US04300557 (121 worldwide citation)

An improved process for dispensing a lipid soluble labile drug, i.e. 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) by diffusion through a silicone capsule implanted at a periocular site to an intraocular site within an animal body being treated with the drug, the improvements wherein the silicone cap ...


8
George F Vande Woude, William L McClements, Marianne K Oskarsson, Donald G Blair: LTR-Vectors. The United States of America represented by the Department of Health and Human Services, John S Roberts Jr, September 20, 1983: US04405712 (110 worldwide citation)

The production of vectors composed of portions of retrovirus, particularly of Moloney sarcoma virus DNA including the "LTR" sequence which can activate genes and additional viral sequences which can "rescue" these genes into a replicating virus particle.


9
Thomas A Kunkel: Process for site specific mutagenesis without phenotypic selection. The United States of America represented by the Department of Health and Human Services, John S Roberts Jr, Mishrilal Jain, October 10, 1989: US04873192 (107 worldwide citation)

The present invention discloses several DNA mutagenesis processes using a DNA template containing several uracil residues in place of thymine, which can be applied without selection techniques to produce altered DNA sequences with approximately 10-fold greater efficiency than current methods of site ...


10
Ira Pastan, Mark C Willingham, David J Fitzgerald: Pseudomonas exotoxin conjugate immunotoxins. The United States of America represented by the Secretary Dept of Health and Human Services, John S Roberts Jr, October 8, 1985: US04545985 (91 worldwide citation)

A method of modifying Pseudomonas exotoxin (PE) with methyl-4-mercaptobutyrimidate is disclosed so that after conjugating the exotoxin to a monoclonal antibody (ab) such as the antibody to the transferrin receptor, the PE-ab conjugate becomes a highly potent immunotoxin suitable for use against huma ...



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