1
Rainer Alex, Paul Hadvary, Hansjorg Tschirky: Dermally affixed injection device. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, August 3, 1999: US05931814 (484 worldwide citation)

An improved injection device has a casing containing an active substance reservoir, a cannula communicating with the reservoir, a device for inserting the cannula, and pump means for discharging the reservoir contents through the cannula. The cannula 11 is fixed relative to the casing and projects b ...


2
Giorgio Cirelli, Benno Rothenhausler, Hans Steffen: Device for introducing active substance into a patient. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, December 15, 1998: US05848990 (213 worldwide citation)

A device for introducing an active substance solution into a patient and with means for fastening to the skin and a cannula. The cannula is held in a withdrawn position by a retaining and releasing mechanism before use and, after release, is propelled into the patient's skin. A connector connected t ...


3
Rolf Moser, Lukas Birrer: Thermal cycler. Roche Diagnostic Systems, George W Johnston, William H Epstein, John P Parise, August 18, 1998: US05795547 (129 worldwide citation)

An apparatus for automatic performance of temperature cycles in a number of test tubes in which each test tube is closed by a closure and contains a predetermined volume of a liquid reaction mixture. The apparatus includes a holder, a computer-controlled automatic control system, and a device for cy ...


4
Rolf Knobel: Analytical device for separating magnetic microparticles from suspensions. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, January 6, 1998: US05705062 (105 worldwide citation)

An analytical device separates magnetic microparticles from a suspension. The separating portion of the device contains two permanent magnets between which the reaction vessel containing the suspension is disposed. For the purpose of more rapid, complete separation of the magnetic microparticles, ma ...


5
Vladimir G Chigrinov, Vladimir M Kozenkov, Nicolic V Novoseletsky, Victor Y Reshetnyak, Yuriy A Reznikov, Martin Schadt, Klaus Schmitt: Process for making photopolymers having varying molecular orientation using light to orient and polymerize. Hoffmann La Roche, Niopic Moscow Research and Production Association, Geroge M Gould, George W Johnston, John P Parise, February 14, 1995: US05389698 (102 worldwide citation)

An oriented photopolymer is a polymer where photomodification is initiated by irradiation with plane-polarized light and where the molecular configuration has a preferred orientation as a result of linear polarization. These polymers have optically anisotropic and other novel properties.


6
Rolf Moser, Lukas Birrer: Thermal cycler. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, April 1, 1997: US05616301 (86 worldwide citation)

An apparatus for automatic performance of temperature cycles in a number of test tubes in which each test tube is closed by a closure and contains a predetermined volume of a liquid reaction mixture. The apparatus includes a holder, a computer-controlled automatic control system, and a device for cy ...


7
Pierre Barbier, Paul Hadvary, Hans Lengsfeld: Method of reducing gastrointestinal side effects associated with orlistat treatment. Hoffmann La Roche, George W Johnston, John P Parise, June 29, 2004: US06756364 (86 worldwide citation)

A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.


8
Jurg Buhler, Siegfried Muller: Vessel holder for automated analyzer. Roche Diagnostic Systems, George W Johnston, William H Epstein, John P Parise, December 23, 1997: US05700429 (80 worldwide citation)

A vessel holder for receiving a number of vessels is useful in an automated analyzer. To increase the number of vessels which can be received in the analyzer and to simplify the device for reading bar code labels, the vessel holder has an elongate body manufactured in one piece and containing a sing ...


9
Hans Peter Haar, Manfred Beuttenm├╝ller, Markus Mattern, George Bevan Meacham: Hypodermic injection system. Roche Diagnostics, George W Johnston, William H Epstein, John P Parise, July 10, 2001: US06258063 (79 worldwide citation)

A hypodermic injection system allows for the generation of a high pressure liquid jet capable of passing through the skin. The system uses two regions, the first region being flexible or squeezable and the second region having at least one exiting orifice through which the liquid jet can be expelled ...


10
Manfred Brockhaus, Zlatko Dembic, Reiner Gentz, Werner Lesslauer, Hansruedi Lotscher, Ernst Jurgen Schlaeger: DNA encoding a human TNF binding protein. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, September 15, 1998: US05808029 (75 worldwide citation)

The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions) ...