51
William Bauer Jr, Josefina Tseng Chapman, Mario Giuseppe Luciano Mirabelli, Jeremia Jesaja Venter: Process for producing butyl acrylate. Rohm and Haas Company, John L Lemanowicz, March 2, 1999: US05877345 (3 worldwide citation)

An improved process for producing n-butyl acrylate in high yield and high purity substantially free of acrylic acid, incorporates one or more of the following new process components in an acid-catalyzed esterification process for producing n-butyl acrylate:


52
Jeffrey Mark Besterman, Michael Glenn Evans, Karen Elizabeth Lackey, Michael Joseph Luzzio, Michael Robert Peel, Daniel David Sternbach: Water soluble camptothecin derivatives. Glaxo Wellcome, John L Lemanowicz, August 8, 2000: US06100273 (3 worldwide citation)

The present invention relates to water soluble, camptothecin derivatives of formula (I). ##STR1## wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): ##STR2## X is selected from the group consisting of alkyl, aryl, (CH.sub.2).sub.m OR.sup.1, (CH.sub.2).sub.m SR.sup.1 and (CH.sub.2).s ...


53
Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J Silva, Jun Tang: 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof. SmithKline Beecham Corporation, John L Lemanowicz, September 23, 2008: US07427623 (3 worldwide citation)

Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


54
Stanley Dawes Chamberlain, Mui Cheung, Holly Kathleen Emerson, Neil W Johnson, Kristen Elizabeth Nailor, Douglas McCord Sammond, Marcus Semones: Diamino-pyrimidines and their use as angiogenesis inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, Jennifer L Fox, March 4, 2008: US07338959 (3 worldwide citation)

Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


55
Ronnie Lee Hale, Brad Richard Henke, Millard Hurst Lambert III, Amy Tsai Lu, Paul Kenneth Spearing, Philip Stewart Turnbull: Piperazinyltriazines as estrogen receptor modulators. SmithKline Beecham Corporation, John L Lemanowicz, September 13, 2005: US06943162 (3 worldwide citation)

Triazine derivatives of formula (I), which exhibit pharmacological activity at estrogen receptors alpha (ER alpha) and beta (ER beta) are described herein. The described invention also includes compositions and medicaments containing the triazine derivatives as well as processes for the preparation ...


56
Enrique Luis Michelotti, Anne Ritchie Egan, Ronald Ross Jr, Willie Joe Wilson: Dihydropyridazinones, pyridazinones and related compounds as fungicides. Rohm and Haas Company, John L Lemanowicz, Joseph F Leightner, March 10, 1998: US05726176 (2 worldwide citation)

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.


57
Enrique Luis Michelotti, Anne Ritchie Egan, Ronald Ross Jr, Willie Joe Wilson: Dihydropyridazinones, pyridazinones and related compounds as fungicides. Rohm and Haas Company, John L Lemanowicz, Joseph F Leightner, March 17, 1998: US05728698 (2 worldwide citation)

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.


58
Enrique Luis Michelotti, Anne Ritchie Egan, Ronald Ross Jr, Willie Joe Wilson: Dihydropyridazinones, pyridazinones and related compounds as fungicides. Rohm and Haas Company, John L Lemanowicz, Joseph F Leightner, March 17, 1998: US05728715 (2 worldwide citation)

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.


59
Enrique Luis Michelotti, Anne Ritchie Egan, Ronald Ross Jr, Willie Joe Wilson: Dihydropyridazinones, pyridazinones and related compounds as fungicides. Rohm and Haas Company, John L Lemanowicz, Joseph F Leightner, March 17, 1998: US05728694 (2 worldwide citation)

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.


60
Enrique Luis Michelotti, Anne Ritchie Egan, Ronald Ross Jr, Willie Joe Wilson: Dihydropyridazinones, pyridazinones and related compounds as fungicides. Rohm and Haas Company, John L Lemanowicz, Joseph F Leightner, March 10, 1998: US05726162 (2 worldwide citation)

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.