Jan H M Schellens: Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents. Smith Kline Beecham Corporation, John L Lemanowicz, October 22, 2002: US06469022 (16 worldwide citation)

A combination of 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7,-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridinecarboxamide or a salt thereof and paclitaxel and its analogs or derivatives.

Kimberley Caroline Glennon, Lee Frederick Kuyper, Karen Elizabeth Lackey, Robert Walton Mcnutt Jr: 3-(anilinomethylene) oxindoles. Glaxo Wellcome, John L Lemanowicz, February 26, 2002: US06350747 (14 worldwide citation)

The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways ...

Zehong Wan, Joelle L Burgess, James F Callahan: NF-κB inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, James C Kellerman, Laura K Madden, January 23, 2007: US07166639 (13 worldwide citation)

The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in which diseases excessive activation o ...

Jerry Leroy Adams, Domingos J Silva: Chemical compounds. SmithKline Beecham Corporation, Loretta Sauermelch, James Kellerman, John L Lemanowicz, February 20, 2007: US07179836 (13 worldwide citation)

Thiophene derivatives are described herein. The described invention also includes methods of making such thiophene derivatives as well as methods of using the same in the treatment of diseases.

Francis Gerard Fang, Edward McDonald Huie, Shiping Xie, Daniel L Comins: Preparation of a camptothecin derivative by intramolecular cyclisation. Glaxo Wellcome, North Carolina State University, John L Lemanowicz, Lorie Ann Morgan, May 16, 2000: US06063923 (12 worldwide citation)

The present invention relates to a method for the preparation of camptothecin and camptothecin-like compounds and to novel intermediates used in this preparation. In particular, the invention provides a process for the preparation of the camptothecin derivative of formula (I') known by the chemical ...

Karen Elizabeth Lackey, Robert Walton McNutt Jr: 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors. SmithKlineBeecham Corporation, John L Lemanowicz, December 24, 2002: US06498176 (12 worldwide citation)

Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.


William Bauer Jr, Timothy Allen Hale, Robert Michael Mason, Rita Karina Upmacis, Lori Marie Petrovich: Process for pure grade acrylic acid. Rohm and Haas Company, Kevin F Gironda, John L Lemanowicz, June 2, 1998: US05759358 (11 worldwide citation)

Processes are provided for producing a pure grade of acrylic acid having residual aldehyde levels under 10 parts per million. The processes apply selected groups of amines sequentially and, preferably, continuously in selectively reducing, for example, acrolein and furfural, and may be advantageousl ...

Malcolm Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith: Heterocyclic compounds. SmithKline Beecham Corporation, John L Lemanowicz, September 19, 2006: US07109333 (9 worldwide citation)

A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II)  wherein L and L′ are suitable leaving groups, with a compound of formula (III) UNH2  (III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by ...