1
George Ferdinand Rowland: Immunological materials. G D Searle & Co, John J McDonnell, September 6, 1977: US04046722 (174 worldwide citation)

The present invention is concerned with a cytotoxic agent comprising an immunoglobulin specific for antigens on the surface of the cell to be killed having 1-10 polymer carrier molecules covalently bonded thereto and the polymer carrier having 5-500 molecules of a cytotoxic drug covalently bound. Th ...


2
Yie W Chien, Howard J Lambert: Method for making a microsealed delivery device. G D Searle & Co, John J McDonnell, November 16, 1976: US03992518 (103 worldwide citation)

The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biolo ...


3
Chao Huei J Wang, Stephen D Stroupe, Michael E Jolley: Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins. Abbott Laboratories, Steven M Odre, John J McDonnell, Robert L Niblack, December 13, 1983: US04420568 (80 worldwide citation)

An immunochemical method and reagent compounds for determining ligands in a sample. The reagent compounds are derivatives of a triazinylaminofluorescein and are represented by the structural formula ##STR1## wherein Y is halo or lower alkyl; and


4
John A Colliopoulos, Nicholas S Yanick: Vegetable oil emulsion. G D Searle & Co, John J McDonnell, June 29, 1976: US03966632 (77 worldwide citation)

The present invention is concerned with a vegetable oil emulsion containing from 1-10% water, preferably 1-5% water, and 1-4% emulsifying agent. The emulsifying agent is a particular mixed polyglycerol ester of 12-hydroxy-9 octadecenoic acid or of dimerized fatty acids of soybean oil. These water-in ...


5
John S Baran, Chi Dean Liang: Octahydronapthalenes. G D Searle & Co, John J McDonnell, February 12, 1985: US04499289 (74 worldwide citation)

The invention relates to octahydronapthalenes which are useful in antiatherosclerotic agents.


6
Gordon K Korom: Test tube decanter rack. Abbott Laboratories, John J McDonnell, August 18, 1981: US04284603 (51 worldwide citation)

An apparatus useful in expediting the performance of immunochemical determinations which require the complete separation of a solid phase or precipitate from a liquid phase is disclosed. In particular, this apparatus features a test tube rack and cooperating retaining means for spanning said rack an ...


7
John A Colliopoulos, David B Paul, James G Young: Psyllium hydrophilic mucilloid composition. G D Searle & Co, John J McDonnell, July 10, 1984: US04459280 (45 worldwide citation)

This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.


8
Richard A Mueller: Dibenzoxazepine N-carboxylic acid hydrazines and derivatives. G D Searle & Co, John J McDonnell, November 16, 1976: US03992375 (39 worldwide citation)

Derivatives of the dibenzoxazepine N-carboxylic acid hydrazides are acylated to yield N,N'-diacyl hydrazines which are useful pharmacological agents as is evidenced by their anti-arrhythmic, anti-inflammatory, anti-diarrheal, prostaglandin antagonist and 5-hydroxytryptamine antagonist activity.


9
Richard A Mueller: 1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof. G D Searle & Co, John J McDonnell, August 30, 1977: US04045442 (38 worldwide citation)

The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.


10
Richard A Mueller: 1-[5-(2-Azabicyclo[2.2.2]oct-2-ylpentanoyl]-2-(dibenz-oxazepine-1 0-carbonyl)hydrazines. G D Searle & Co, John J McDonnell, November 14, 1978: US04125532 (37 worldwide citation)

The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.