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James Aggen, John H Griffin, Mathai Mammen, Daniel Marquess, Edmund J Moran, David Oare: Muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Joyce G Cohen, February 17, 2004: US06693202 (123 worldwide citation)

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modu ...


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Mathai Mammen, David Oare: Therapeutic ureas. Theravance, Jeffrey A Hagenah, David E Boone, October 21, 2003: US06635764 (76 worldwide citation)

This invention relates to urea compounds that are muscarinic receptor antagonists and agonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.


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Mathai Mammen, Sarah Dunham, Adam Hughes, Tae Weon Lee, Craig Husfeld, Eric Stangeland, Yan Chen: Biphenyl derivatives. Theravance, Jeffrey A Hagenah, November 28, 2006: US07141671 (64 worldwide citation)

This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor a ...


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Edmund J Moran, Seok Ki Choi: &bgr;2-adrenergic receptor agonists. Theravance, David E Boone, Jeffrey A Hagenah, Roberta P Saxon, April 1, 2003: US06541669 (54 worldwide citation)

Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


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Edmund J Moran, John H Griffin, Seok Ki Choi: &bgr;2-adrenergic receptor agonists. Theravance, David E Boone, Jeffrey A Hagenah, Roberta P Saxon, June 10, 2003: US06576793 (48 worldwide citation)

Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


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Mathai Mammen, Sarah Dunham: adrenergic receptor agonist and muscarinic receptor antagonist activity, Compounds having β. Theravance, Jeffrey A Hagenah, Connie C Tong, March 18, 2008: US07345060 (34 worldwide citation)

The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comp ...


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Mathai Mammen, Yu Hua Ji, YongQi Mu, Craig Husfeld, Li Li: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, October 30, 2007: US07288657 (34 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compo ...



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