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Jaroskova Libuse, Linders Joannes Theodorus Maria, Buyck Christophe Francis Robert Nestor, Van Der, Veken Louis Jozef Elisabeth: Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors. Janssen Pharmaceutica, Jaroskova Libuse, Linders Joannes Theodorus Maria, Buyck Christophe Francis Robert Nestor, Van Der, Veken Louis Jozef Elisabeth, JANSSEN PHARMACEUTICA, November 17, 2005: WO/2005/108361 (81 worldwide citation)

The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4a ...


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Huang Shenlin, Lin Ronghui, Connolly Peter J, Emanuel Stuart L, Middleton Steven A: Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders. Janssen Pharmaceutica, Huang Shenlin, Lin Ronghui, Connolly Peter J, Emanuel Stuart L, Middleton Steven A, JANSSEN PHARMACEUTICA, May 11, 2006: WO/2006/050076 (60 worldwide citation)

The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhibitors useful in treating or ameliorating a kinase mediated, angiogenesis-med ...


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Vandecruys Roger Petrus Gerebern: Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base. Janssen Pharmaceutica, Vandecruys Roger Petrus Gerebern, JANSSEN PHARMACEUTICA, June 17, 2004: WO/2004/050068 (56 worldwide citation)

The invention provides a novel pharmaceutical composition comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base characterized in that the acid respectively base:drug compound ratio is at least 1:1 by weight.


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Freyne Eddy Jean Edgard, Love Christopher John, Cooymans Ludwig Paul, Vandermaesen Nele, Buijnsters Peter Jacobus Johannes Antonius, Willems Marc, Embrechts Werner Constant Johan: Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors. Janssen Pharmaceutica, Freyne Eddy Jean Edgard, Love Christopher John, Cooymans Ludwig Paul, Vandermaesen Nele, Buijnsters Peter Jacobus Johannes Antonius, Willems Marc, Embrechts Werner Constant Johan, JANSSEN PHARMACEUTICA, February 10, 2005: WO/2005/012304 (38 worldwide citation)

This invention concerns compounds of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochernically isomeric form thereof, wherein ring A represents phenyl, pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R1 represents hydrogen; aryl; formyl; C1-6 alky ...


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