41
Ross G Clark, Michael J Cronin, Douglas A Yeung, James Q Oeswein: Growth-promoting composition and its use. Genentech, Janet E Hasak, December 20, 1994: US05374620 (44 worldwide citation)

A combined formulation for IGF-I and growth hormone (GH) is useful for enhancing growth of a mammal. This formulation, which may be administered by infusion or injection to enhance growth, comprises IGF-I and GH, each in amounts of 0.1 to 100 mg/ml, in a pharmaceutically acceptable carrier at a pH o ...


42
Stuart Bunting, Ross Clark, Nancy Gillett, Hongkui Jin, Renhui Yang: Treatment of congestive heart failure. Genentech, Janet E Hasak, August 10, 1999: US05935924 (44 worldwide citation)

A mammal with congestive heart failure is treated by administering to the mammal an effective amount of growth hormone. Treatment results in increased left ventricular cystolic pressure, increased left ventricular maximum, increased cardiac output, and increased stroke volume index. Treatment also r ...


43
Will Bloch, Patrick J Sheridan, Robert J Goodson: Ionic compounds containing the cationic meriquinone of a benzidine. Cetus Corporation, Albert P Halluin, Janet E Hasak, Dianne E Reed, December 6, 1988: US04789630 (44 worldwide citation)

Useful for visualizing biological materials in a solid phase, on a gel, or in a liquid phase is a solid salt of the meriquinone of benzidine or a substituted benzidine. An immobilized or dissolved complex of a polymeric anion and the meriquinone of benzidine or a substituted benzidine having control ...


44
Guido Sartori, Chang J Kim, Michael T Melchior, David W Savage: Process for removing acid gases using a basic salt activated with a non-sterically hindered diamine. Exxon Research and Engineering Co, Janet E Hasak, March 8, 1983: US04376101 (43 worldwide citation)

Acidic gases containing carbon dioxide are removed from a normally gaseous mixture by absorbing CO.sub.2 from the gaseous mixture with an aqueous solution comprising a basic alkali metal salt or hydroxide and an activator or promoter system for the salt or hydroxide which contains (i) at least one n ...


45
Arthur J Ammann, Christopher G Rudman: Method of inducing bone growth using TGF-.beta.. Genentech, Janet E Hasak, February 18, 1997: US05604204 (39 worldwide citation)

A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acc ...


46
Baha M Alak, Richard L Stouffer, Don P Wolf, Teresa K Woodruff: Enhancement of fertilization capability of oocytes. Genentech, Oregon Regional Primate Research Center, Janet E Hasak, December 2, 1997: US05693534 (39 worldwide citation)

A method is provided for increasing the fertilization potential of oocytes comprising culturing oocytes in vitro with an effective amount of inhibin, activin, or a combination of inhibin and activin. Preferably the oocytes being cultured are immature. After the culturing step, the oocytes can be fer ...


47
Francis P McCormick, Michael A Innis, Gordon M Ringold: Expression of interferon genes in Chinese hamster ovary cells. Cetus Corporation, Philip L McGarrigle, Janet E Hasak, Albert P Halluin, October 30, 1990: US04966843 (39 worldwide citation)

DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced conta ...


48
Lois Aldwin, Danute E Nitecki: Solubilization of proteins for pharmaceutical compositions using polyproline conjugation. Cetus Corporation, Philip L McGarrigle, Janet E Hasak, Albert P Halluin, January 16, 1990: US04894226 (38 worldwide citation)

A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at pH 6-8 without such solubilizing agent, is covalently conjugated ...


49
Stuart Builder, Roger Hart, Philip Lester, John Ogez, David Reifsnyder: Aqueous multiple-phase isolation of polypeptide. Genentech, Janet E Hasak, April 18, 1995: US05407810 (37 worldwide citation)

A method is described for isolating an exogenous polypeptide in a non-native conformation from cells, such as an aqueous fermentation broth, in which it is prepared comprising contacting the polypeptide with a chaotropic agent and preferably a reducing agent and with phase-forming species to form mu ...


50
Chung N Chang, Ronald A Hitzeman, Mark D Matteucci: Use of yeast homologous signals to secrete heterologous proteins. Genentech, Janet E Hasak, April 23, 1991: US05010003 (37 worldwide citation)

Described herein is the secretion from yeast of heterologous protein via a preprotein in which the heterologous protein is fused to the signal peptide of a yeast protein. The preprotein is processed by the cells to produce and secrete mature heterologous protein.