1
Kary B Mullis: Process for amplifying nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683202 (3921 worldwide citation)

The present invention is directed to a process for amplifying any desired specific nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, and extending ...


2
Kary B Mullis, Henry A Erlich, Norman Arnheim, Glenn T Horn, Randall K Saiki, Stephen J Scharf: Process for amplifying, detecting, and/or-cloning nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683195 (3326 worldwide citation)

The present invention is directed to a process for amplifying and detecting any target nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending ...


3
Kary B Mullis, Henry A Erlich, David H Gelfand, Glenn Horn, Randall K Saiki: Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme. Cetus Corporation, Kevin R Kaster, Janet E Hasak, Albert P Halloin, October 23, 1990: US04965188 (1277 worldwide citation)

A process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers and extending the primers with a thermostable enzyme to form complementary ...


4
Kary B Mullis, Henry A Erlich, Norman Arnheim, Glenn T Horn, Randall K Saiki, Stephen J Scharf: Process for amplifying, detecting, and/or cloning nucleic acid sequences. Cetus Corporation, Kevin R Kaster, Janet E Hasak, Albert P Halluin, January 24, 1989: US04800159 (1057 worldwide citation)

The present invention is directed to a process for amplifying and detecting any target nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending ...


5
David H Gelfand, Susanne Stoffel, Frances C Lawyer, Randall K Saiki: Purified thermostable enzyme. Cetus Corporation, Janet E Hasak, Kevin R Kaster, Albert P Halluin, December 26, 1989: US04889818 (413 worldwide citation)

A purified thermostable enzyme is obtained that has unique characteristics. Preferably the enzyme is isolated from the Thermus aquaticus species and has a molecular weight of about 86,000-90,000 daltons. The thermostable enzyme may be native or recombinant and may be used in a temperature-cycling ch ...


6
Nandini Katre, Michael J Knauf: Solubilization of proteins for pharmaceutical compositions using polymer conjugation. Cetus Corporation, Albert P Halluin, Janet E Hasak, August 23, 1988: US04766106 (292 worldwide citation)

A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not r ...


7
Randall K Saiki, Henry A Erlich: Method for detection of polymorphic restriction sites and nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683194 (281 worldwide citation)

In a method for detecting the presence or absence of a specific restriction site in a nucleic acid sequence an oligonucleotide probe complementary to one strand of the nucleic acid sequence spanning said restriction site is synthesized. The probe is labeled at the end nearer the restriction site. Th ...


8
Nandini Katre, Robert F Halenbeck, Robert J Goodson, Peter C McCabe, Michael J Knauf: Interleukin-2 muteins and polymer conjugation thereof. Cetus Oncology Corporation, Philip L McGarrigle, Janet E Hasak, April 27, 1993: US05206344 (218 worldwide citation)

Muteins of IL-2 in which one of the amino acids of the mature native sequence of IL-2 is replaced by a cysteine residue are prepared and conjugated through the replaced cysteine residue to a polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols, wherein said homopolymers ...


9
Leonard G Presta, Bradley R Snedecor: Altered polypeptides with increased half-life. Genentech, Janet E Hasak, April 14, 1998: US05739277 (211 worldwide citation)

Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.


10
Henry A Erlich: HLA typing method and cDNA probes used therein. Cetus Corporation, Albert P Halluin, Janet E Hasak, Thomas E Ciotti, April 15, 1986: US04582788 (175 worldwide citation)

HLA typing based on restriction length polymorphism is carried out by: digesting an individual's HLA DNA with a restriction endonuclease that produces a polymorphic digestion pattern with HLA DNA; subjecting the digest to genomic blotting using a labeled cDNA hybridization probe that is complementar ...



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