1
Raju Kucherlapati, Aya Jakobovits: Method of making transgenic mice lacking endogenous heavy chains. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 17, 1999: US05939598 (541 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


2
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (335 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


3
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (291 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


4
Douglas Charles Hanson, Mark Joseph Neveu, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Steven Christopher Gilman, C Geoffrey Davis, Jose Ramon Corvalan: Human monoclonal antibodies to CTLA-4. Abgenix, Pfizer, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, January 27, 2004: US06682736 (95 worldwide citation)

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and ...


5
Bruce D Cohen, Jean Beebe, Penelope E Miller, James D Moyer, Jose R Corvalan, Michael Gallo: Antibodies to insulin-like growth factor I receptor. Abgenix, Pfizer, Fish & Neave IP Group Ropes & Gray, James F Haley Jr Esq, Jane T Gunnison Esq, May 2, 2006: US07037498 (40 worldwide citation)

The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single ...


6
Richard A Flavell, Fred S Kantor, Stephen W Barthold, Erol Fikrig: Compositions and methods for the prevention and diagnosis of lyme disease. Yale University, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, May 5, 1998: US05747294 (15 worldwide citation)

Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme disease as caused by infection with B. burgdo ...


7
Douglas Charles Hanson, Mark Joseph Neveu, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Steven Christopher Gilman, C Geoffrey Davis, Jose Ramon Corvalan: Methods for expressing and recovering human monoclonal antibodies to CTLA-4. Abgenix, Pfizer, Fish & Neave IP Group Ropes & Gray, James F Haley Jr Esq, Jane T Gunnison Esq, September 19, 2006: US07109003 (12 worldwide citation)

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and ...


8
Richard A Flavell, Fred S Kantor, Stephen W Barthold, Erol Fikrig: Compositions and methods for the prevention and diagnosis of Lyme disease. Yale University, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, March 6, 2001: US06197301 (8 worldwide citation)

Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme disease as caused by infection with


9
Richard A Flavell, Erol Fikrig, Tuan T Lam, Fred S Kantor, Stephen W Barthold: OspE, OspF, and S1 polypeptides in borrelia burgdorferi. Yale University, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 12, 1997: US05656451 (5 worldwide citation)

Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel B. burgdor ...


10
Thomas F Tedder: Lymphocyte-associated cell surface protein. Dana Farber Cancer Institute, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, February 1, 2000: US06020152 (1 worldwide citation)

A human cDNA sequence encoding lymphocyte-associated cell surface protein LAM-1, which contains domains homologous with binding domains of animal lectins, growth factors, and C3/C4 binding proteins, and the LAM-1 protein encoded by the cDNA sequence, are described. Antagonists to LAM-1 are used in a ...