61
Arthur A Nagel: Alkylated oleandomycin containing compounds. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, January 31, 1984: US04429116 (2 worldwide citation)

A process for the alkylation of the C.sub.3 " position of oleandomycin and antibacterial agents derived therefrom.


62
Lawrence S Melvin Jr: Oxindole antiinflammatory agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, February 17, 1987: US04644005 (2 worldwide citation)

Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl oxindole-3-carboxylate.


63
Lawrence S Melvin Jr: Oxindole antiinflammatory agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, August 11, 1987: US04686224 (2 worldwide citation)

Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl oxindole-3-carboxylate.


64
Kelvin Cooper, John Steele, Kenneth Richardson: Dihydropyridine anti-allergic and anti-inflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, August 22, 1989: US04859686 (2 worldwide citation)

4-Aryl-3-alkoxycarbonyl-6-methyl-5-carbamyl-2-triazolylalkoxymethyl-1,4-dih yd ropyridines as anti-allergic and anti-inflammatory agents.


65
Kelvin Cooper, Michael J Fray, Kenneth Richardson, John Steele: 1,4-dihydropyridine derivatives. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, October 16, 1990: US04963560 (2 worldwide citation)

The invention provides compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by halo;


66
David Alker, Peter E Cross, Simon F Campbell: Dihydropyridine anti-ischaemic and anti-hypertensive agents, compositions and use. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, October 22, 1985: US04548935 (2 worldwide citation)

Dihydropyridine anti-ischaemic and anti-hypertensive agents of the formula: ##STR1## and their pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 or 2-methoxyethyl; n is 1 or 2; m is 1, 2 or 3; X is a 5 or 6 membered aromat ...


67
Kelvin Cooper, Michael J Fray, Kenneth Richardson, John Steele: Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, September 22, 1992: US05149814 (2 worldwide citation)

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.


68
Walter P Cullen, John R Oscarson, Junsuke Tone, Hiroshi Maeda: Inophore antibacterial agent from streptomyces. Pfizer, Peter C Richardson, Albert E Frost, James M McManus, June 14, 1988: US04751317 (2 worldwide citation)

An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.


69
Simon F Campbell, Peter E Cross, John K Stubbs: Dihydropyridine anti-ischaemic and antihypertensive agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, October 7, 1986: US04616024 (1 worldwide citation)

1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl: R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; Y is --(CH.sub.2).sub.n --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --; n is 1 to 3; and X is a 5 or 6 memb ...


70
Simon F Campbell, Peter E Cross, John K Stubbs: Dihydropyridines and their use in treating cardiac conditions and hypertension. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, October 15, 1985: US04547502 (1 worldwide citation)

1,4-Dihydropyridine derivatives of the formula ##STR1## and their pharmaceutically acceptable acid addition salts; where: