51
James R Hauske: 3",4"-Oxyallylene erythromycin and oleandomycin, composition and method of use. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, December 14, 1982: US04363803 (3 worldwide citation)

The reaction product of dimethyl diazomethylphosphonate with 4"-deoxy-4"-oxo-oleandomycin and erythyromycin A derivatives as antibacterial agents.


52
Kelvin Cooper, Michael J Fray, Kenneth Richardson, John Steele: 1,4-dihydro-2-(4-[benzimidazol-l-yl]phenyl)-pyridines as platelet activating factor antagonists. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, November 5, 1991: US05063237 (3 worldwide citation)

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, ...


53
Vytautas J Jasys: Process for the preparation of penicillanic acid esters. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, April 26, 1983: US04381263 (3 worldwide citation)

A process for the preparation of chloromethyl esters of penicillanic acids, using iodochloromethane or bromochloromethane and a tetraalkylammonium salt of the penicillanic acid, and their use in processes for the synthesis of penicillanic acid esters, using a halomethyl ester and the tetraalkylammon ...


54
David Alker, Simon F Campbell, Peter E Cross: 2-oxygen containing heteroalkoxyalkyl dihydropyridine intermediates. Pfizer, Peter C Richardson, Albert E Frost, James M McManus, March 22, 1988: US04732985 (3 worldwide citation)

1,4-Dihydropyridine anti-ischaemic and antihypertensive agent of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is 2-chlorophenyl, 2,3-dichlorophenyl or 2-chloro-3-trifluoromethylphenyl;


55
Arthur A Nagel, James P Rizzi, Terry J Rosen: Heterocyclicguanidines as 5HT.sub.3 antagonists. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, October 16, 1990: US04963689 (3 worldwide citation)

Heterocyclicguanidines as 5HT.sub.3 antagonists useful in the treatment of nausea, anxiety, pain, schizophrenia and gastrointestinal disorders.


56
Walter D Celmer, Walter P Cullen, Hiroshi Maeda, Junsuke Tone: Streptomyces capable of producing neutral macrolide antibacterial agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, September 24, 1985: US04543334 (3 worldwide citation)

An antibiotic complex, consisting of one major and two minor components, has been isolated from fermentation of a new Streptomyces culture. The components from the complex are three new macrolides which are active as antibacterial agents against certain gram-negative and gram-positive microorganisms ...


57
David Alker, Simon F Campbell, Peter E Cross: Dihydropyridine anti-ischaemic and antihypertensive agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, January 9, 1990: US04892881 (3 worldwide citation)

1,4-Dihydropyridine anti-ischaemic and antihypertensive agent of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is 2-chlorophenyl, 2,3-dichlorophenyl or 2-chloro-3-trifluoromethylphenyl;


58
John A Lowe III: Process for (1H)-isoindolin-1-one-3-carboxylic acid. Pfizer, Peter C Richardson, Albert E Frost, James M McManus, March 8, 1988: US04730056 (3 worldwide citation)

A process for preparing [1H]-isoindolin-1-one-3-carboxylic acid comprising the steps of (1) reacting phthalaldehydic acid in an alkanol with ammonia, (2) contacting the resulting solution with an alkali metal cyanide, (3) removing the alkanol, (4) adjusting the pH to 1.0, (5) heating the resulting r ...


59
Ernest S Hamanaka, John G Stam: Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, June 4, 1985: US04521533 (2 worldwide citation)

Salts of readily hydrolyzable esters of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide and (a) prodrug forms of ampicillin and amoxicillin or (b) ampicillin and amoxicillin and a dibasic acid are readily absorbed following oral adminstration, and are useful in treating bacterial infections.


60
Kenneth Richardson, Kelvin Cooper: Bistriazole antifungal agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, August 21, 1984: US04466974 (2 worldwide citation)

Compounds of the formula ##STR1## wherein X is an amine function and R is substituted phenyl and their pharmaceutically acceptable salts are useful antifungal agents in animals, including man.