41
Geoffrey E Gymer, Kenneth Richardson: Triazole antifungal agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, October 2, 1990: US04960782 (5 worldwide citation)

Triazoles of the formula ##STR1## where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, or R is 5-chloro-pyrid-2-yl; and R.sup.1 is H, CH.sub.3 or F; and their pharmaceutically and ...


42
Lawrence S Melvin: Tricyclic oxindole antiinflammatory agents. Pfizer, Peter C Richardson, Albert E Frost, James M McManus, September 22, 1987: US04695571 (5 worldwide citation)

Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents useful in the treatment of rheumatoid arthritis.


43
Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, April 9, 1991: US05006541 (5 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


44
David Alker, Peter E Cross, Simon F Campbell: 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, February 4, 1986: US04568677 (5 worldwide citation)

1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; X is a 5 or 6 membered nitrogen-containing heterocyclic ring which is substituted with one or more hydroxyl or oxo groups and ...


45
Fredric J Vinick: Process for preparing L-carnosine. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, November 16, 1982: US04359416 (5 worldwide citation)

Process for preparing L-carnosine by reacting L-histidine and tetrahydro-1,3-thiazin-2,4-dione in an aqueous medium at a selected pH and temperature range followed by removal of carbon oxysulfide at acid pH, removal of water and crystallization of product wherein pH adjustments are made with substit ...


46
Kenneth Richardson, Kelvin Cooper: 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, April 9, 1985: US04510148 (4 worldwide citation)

Compounds of the formula ##STR1## wherein R is thienyl, mono-, di- and trihalothienyl, furyl, 2-benzothiazolyl, pyridyl or chloropyridyl and their pharmaceutically acceptable salts are useful agents for combating fungal infections in animals, including humans.


47

48
Kelvin Cooper, Michael J Fray, Kenneth Richardson: Dihydropyridine anti-allergic and anti-inflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, January 31, 1989: US04801598 (4 worldwide citation)

Compounds of the formula: ##STR1## where R is 2-substituted phenyl said substituent being chloro, bromo, cyano, methyl, methylthio, methylsulfonyl, trifluoromethyl, hydroxy, methoxy or benzyloxy; R.sup.1 is hydrogen, lower alkyl, pyridyl, thiazolyl, isoxazolyl, thiadiazdyl or thiazdylmethyl; R.sup.2 ...


49
Conrad Santini: Antiulcer 8-(2-pyrimidylsulfinyl)quinolines. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, February 28, 1989: US04808591 (4 worldwide citation)

8-(2-Pyrimidylsulfinyl)quinolines, inhibitors of the H.sup.+ /K.sup.30 ATPase enzyme, are useful in the treatment of ulcers.


50
Paul D Weeks: 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam. Pfizer, Charles J Knuth, Albert E Frost, James M McManus, March 8, 1983: US04376204 (3 worldwide citation)

Processes for the preparation of the antiinflammatory agent piroxicam and intermediates leading thereto, the first of which comprises reacting N-methylsaccharin with (N-2-pyridyl)haloacetamides and alkyl haloacetates in the presence of a metal hydride to give, respectively, piroxicam and alkyl 4-hyd ...