1
Raju Kucherlapati, Aya Jakobovits: Method of making transgenic mice lacking endogenous heavy chains. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 17, 1999: US05939598 (541 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


2
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (335 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


3
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (291 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


4
Patrick Aebischer, Paul C DiCesare, Moses Goddard, Paul J Mulhauser: Renewable neural implant device and method. Brown University Research Foundation, James F Haley Jr Esq, Ivor R Fish & Neave Elrifi Esq, September 10, 1996: US05554148 (211 worldwide citation)

Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across whi ...


5
Douglas Charles Hanson, Mark Joseph Neveu, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Steven Christopher Gilman, C Geoffrey Davis, Jose Ramon Corvalan: Human monoclonal antibodies to CTLA-4. Abgenix, Pfizer, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, January 27, 2004: US06682736 (95 worldwide citation)

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and ...


6
Spencer B Farr, Marque D Todd: Methods and kits for eukaryotic gene profiling. Pres and Fellows of Harvard College, Xenometrix, James F Haley Jr Esq, Andrew S Marks Esq, Fish & Neave, September 22, 1998: US05811231 (44 worldwide citation)

This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes linked to native eukaryotic stress promoters, especially those of mammals. The kits and methods of this inv ...


7
Bruce D Cohen, Jean Beebe, Penelope E Miller, James D Moyer, Jose R Corvalan, Michael Gallo: Antibodies to insulin-like growth factor I receptor. Abgenix, Pfizer, Fish & Neave IP Group Ropes & Gray, James F Haley Jr Esq, Jane T Gunnison Esq, May 2, 2006: US07037498 (40 worldwide citation)

The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single ...


8
Joseph L Kim, Kurt A Morgenstern, Chao Lin, Ted Fox, John A Thomson: Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex. Vertex Pharmaceuticals Incorporated, James F Haley Jr Esq, Lisa A Dixon, Fish & Neave, November 28, 2000: US06153579 (21 worldwide citation)

The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or ...


9
Joseph L Kim, Kurt A Morgenstern, Chao Lin, Ted Fox, John A Thomson: Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex. Vertex Pharmaceuticals Incorporated, James F Haley Jr Esq, Kristin M Joslyn, Fish & Neave, October 16, 2001: US06303287 (17 worldwide citation)

The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or ...


10
Richard A Flavell, Erol Fikrig, Robert Berland: Flagellin-based polypeptides for the diagnosis of lyme disease. Yale University, James F Haley Jr Esq, Madge r Kanter Esq, Fish & Neave, April 8, 1997: US05618533 (17 worldwide citation)

Diagnostic means and methods for Lyme disease comprising B. burgdorferi flagellin polypeptides and antibodies. Compositions and methods comprising neuroborreliosis-associated antigens useful for the detection, treatment and prevention of neuroborreliosis, arthritis, carditis and other manifestations ...