1
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, June 13, 2000: US06075181 (534 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


2
David C Ward, Pennina R Langer, Alexander A Waldrop III: Modified nucleotides and methods of preparing and using same. Yale University, James F Haley Jr, December 8, 1987: US04711955 (522 worldwide citation)

Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and whe ...


3
Raju Kucherlapati, Aya Jakobovits: Method of making transgenic mice lacking endogenous heavy chains. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 17, 1999: US05939598 (522 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


4
Raju Kucherlapati, Aya Jakobovits, Daniel G Brenner, Daniel J Capon, Sue Klapholz: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, November 21, 2000: US06150584 (430 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


5
Ernst B Hunziker: Method and compositions for the treatment and repair of defects or lesions in cartilage. Robert F Shaw, James F Haley Jr, Jane A Massaro, April 27, 1993: US05206023 (357 worldwide citation)

Methods and compositions are provided for the treatment and repair of defects or lesions in the cartilage of humans and other animals. The defect or lesion in the cartilage may be first treated with an enzyme to remove proteoglycans from the defect area. To induce cartilage formation, the defect is ...


6
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (326 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


7
Harry Meade, Nils Lonberg: Isolation of exogenous recombinant proteins from the milk of transgenic mammals. Biogen, James F Haley Jr, Teresa L Solomon, October 10, 1989: US04873316 (316 worldwide citation)

This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desire ...


8
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (280 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


9
Ernst B Hunziker: Methods and compositions for the treatment and repair of defects or lesions in cartilage. Robert F Shaw, James F Haley Jr, Jane A Massaro, November 29, 1994: US05368858 (271 worldwide citation)

Methods and compositions are provided for the treatment and repair of defects or lesions in the cartilage of humans and other animals. The defect or lesion in the cartilage may be first treated with an enzyme to remove proteoglycans from the defect area. To induce cartilage formation, the defect is ...


10
Patrick Aebischer, Paul C DiCesare, Moses Goddard, Paul J Mulhauser: Renewable neural implant device and method. Brown University Research Foundation, James F Haley Jr Esq, Ivor R Fish & Neave Elrifi Esq, September 10, 1996: US05554148 (201 worldwide citation)

Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across whi ...