1
Henry J Wieck, Paul C Dahlstrom, Dennis W Nixon: Non-contract method for assay reagent volume dispense verification. Chiron Corporation, James E Austin, David P Lentini, Robert P Blackburn, August 1, 2000: US06097831 (149 worldwide citation)

Methods and systems for verifying the volume of a reagent dispensed into an affinity assay vessel are described. In one embodiment, a method is for verifying the volume of a reagent dispensed into an affinity assay vessel described in which a fluid sample is deposited into a vessel that includes a r ...


2
Gregory L DeJager, James R Rivers, David H Yen, Stewart Findlater, Scott A Emery: Port aggregation load balancing. Cisco Technology, James E Austin, Beyer Weaver &Thomas, October 29, 2002: US06473424 (43 worldwide citation)

Provided are methods, apparatuses and systems for balancing the load of data transmissions through a port aggregation. The methods and apparatuses of the present invention allocate port assignments based on load, that is, the amount of data being forwarded through each port in the group. The load ba ...


3
Verena D Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang: Estrogen receptor modulators. Chiron Corporation, Steven W Collier, James E Austin, Alisa A Harbin, March 22, 2005: US06869969 (17 worldwide citation)

Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, ...


4
Edward Almond, Peter Moran: Surgical seal. Applied Medical Resources Corporation, John F Heal, David G Majdali, James E Austin, May 25, 2010: US07722570 (9 worldwide citation)

A seal for laparoscopic port comprising: a base adapted to engage a cannula, the base including an axial aperture for a surgical instrument; a multiplicity of jaws mounted on the base, the jaws being moveable radially with respect to the aperture between an open position wherein the shaft of the sur ...


5
Deborah Charych, Eric Beausoleil, Ronald N Zuckermann: Microarrays on mirrored substrates for performing proteomic analyses. Chiron Corporation, James E Austin, Young J Suh, Alisa A Harbin, December 26, 2006: US07153682 (8 worldwide citation)

Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library synthesis, ...


6
Daniel J Suich, Ronald N Zuckermann: Fluorogenic dyes. Chiron Corporation, James E Austin, Young J Suh, Alisa A Harbin, April 11, 2006: US07026166 (5 worldwide citation)

The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.


7
Deborah Charych, Ronald N Zuckermann: Protein microarrays on mirrored surfaces for performing proteomic analyses. Chiron Corporation, James E Austin, Young J Suh, Alisa A Harbin, December 12, 2006: US07148058 (4 worldwide citation)

Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large arrays of proteins that may be use ...


8
Bradford W Gibson, Irwin D Kuntz, Ning Tang, Gavin Dollinger, Connie M Oshiro, Judith C Hempel, Eric W Taylor, Malin Young: Method of determining the three-dimensional shape of a macromolecule. Chiron Corporation, The Regents of the University of California, James E Austin, Young J Suh, Alisa A Harbin, January 23, 2007: US07167819 (4 worldwide citation)

The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of physical distance constraints, e.g., forming intramolecular chemical crosslinks of known size between residues ...


9
Verena D Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang: Estrogen receptor modulators. Chiron Corporation, James E Austin, Steven W Collier, Robert P Blackburn, April 27, 2004: US06727273 (3 worldwide citation)

Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, th ...


10
Ronald N Zuckermann, Eric Beausoleil, Matthew Wachowicz, Srinivas Kothakota: Biological sample component purification and differential display. Chiron Corporation, James E Austin, Steven W Collier, Robert P Blackburn, August 31, 2004: US06783929 (3 worldwide citation)

Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compatible with biological samples, for ...