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Darren Magda, Jonathan L Sessler, Brent L Iverson, Petra I Sansom, Shaun P Crofts: Method of expanded porphyrin-oligonucleotide conjugate synthesis. Pharmacyclics, Board of Regents Univ of Texas Sys, Jacqueline S Larson, October 15, 1996: US05565552 (193 worldwide citation)

The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-o ...


2
James B Eckenhoff: Delivery device providing beneficial agent stability. ALZA Corporation, Jacqueline S Larson, Edward L Mandell, Steven F Stone, August 11, 1992: US05137727 (191 worldwide citation)

The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeabl ...


3
Jonathan L Sessler, Tarak D Mody, Gregory W Hemmi, Vladimir A Kr al, Darren Magda: Texaphyrin-oligonucleotide conjugates. Pharmacyclics, Board of Trustees Univ of TX Sys, Jacqueline S Larson, December 24, 1996: US05587371 (175 worldwide citation)

Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl ...


4
Judy A Magruder, John R Peery, James B Eckenhoff: Delivery device with a protective sleeve. Alza Corporation, Jacqueline S Larson, Steven F Stone, Edward L Mandell, August 10, 1993: US05234693 (170 worldwide citation)

This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces ...


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Judy A Magruder, John R Peery, James B Eckenhoff: Delivery device with a protective sleeve. Alza Corporation, Jacqueline S Larson, Steven F Stone, Edward L Mandell, August 10, 1993: US05234692 (169 worldwide citation)

This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces ...


6
Donald W Kelley: Lubricious medical devices. Donald W Erickson, Jacqueline S Larson, June 6, 2000: US06071266 (139 worldwide citation)

Lubricious medical devices such as catheters and stents which minimize friction and retain lubricity and dimensional properties for a long period of time. The devices are made by coextrusion wherein the inner layer is a hydrophobic polymer and the outer layer is a blend of a hydrophilic polymer and ...


7
Frederick Maruyama, Richard Cortese: Multi-unit pulsatile delivery system. Alza Corporation, Jacqueline S Larson, Edward L Mandell, Steven F Stone, May 21, 1991: US05017381 (99 worldwide citation)

The present invention is directed to an active agent dispenser for use in a fluid-containing environment, which dispenser comprises a rigid housing, a plurality of movable active agent units filling a portion of the housing, a fluid-activated driving member for dispensing the active agent units fill ...


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Darren Magda, Jonathan L Sessler, Brent Iverson: Chromophore probe for detection of nucleic acid. Pharmacyclics, Board of Trustees Univ of TX Sys, Jacqueline S Larson, January 21, 1997: US05595726 (98 worldwide citation)

The present invention is directed to chromophoric probes for use in detecting nucleic acid sequences. More particularly, the invention is directed to probes that comprise a texaphyrin chromophore molecule covalently coupled or conjugated to a site-directing molecule, the site-directing molecule havi ...


9
Patrick S L Wong, Brian L Barclay, Joseph C Deters, Felix Theeuwes: Controlled-release system with constant pushing source. Alza Corporation, Paul L Sabatine, Edward L Mandell, Jacqueline S Larson, January 21, 1992: US05082668 (72 worldwide citation)

A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combinat ...


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