1
Jean S Kahan, Frederick M Kahan, Edward O Stapley, Robert T Goegelman, Sebastian Hernandez: Antibiotics. Merck & Co, Walter Patton, Julian S Levitt, J Jerome Behan, April 13, 1976: US03950357 (111 worldwide citation)

The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.


2
George T Colegrove: Clarification of xanthan gum. Merck & Co, Donald J Perrella, J Jerome Behan, March 1, 1977: US04010071 (71 worldwide citation)

Fermentation broths and other aqueous suspensions containing a dissolved xanthan gum and suspended solids resulting from the fermentation producing the xanthan gum are clarified by treatment with a minor amount of a protease enzyme. The injectivity of aqueous solutions containing xanthan gum so clar ...


3
Tsung Ying Shen, Arthur F Wagner: Controlled partially cross-linked 3,3-ionenes. Merck & Co, Rudolph J Anderson Jr, J Jerome Behan, Henry H Bassford Jr, January 31, 1978: US04071478 (45 worldwide citation)

The invention disclosed herein relates to novel partially cross-linked, fully quaternized poly-[(methylimino)trimethylene] polymers wherein a minor proportion (1% to 20%) of the nitrogen atoms in adjacent poly-[(methylimino)trimethylene] linear chains are, by quaternization, joined through trimethyl ...


4
Edward J Cragoe Jr, Otto W Woltersdorf Jr: 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids. Merck & Co, Michael C Sudol Jr, J Jerome Behan, October 5, 1976: US03984465 (41 worldwide citation)

1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treat ...


5
Kenneth Suk Kang, William H McNeely: Polysaccharide and bacterial fermentation process for its preparation. Donald J Perrella, J Jerome Behan, Hesna J Pfeiffer, June 1, 1976: US03960832 (41 worldwide citation)

A process for producing a novel heteropolysaccharide by a bacterial fermentation in which a new bacteria is incubated in a final fermentation medium containing a suitable carbohydrate source, a source of magnesium ions, a source of phosphorus and nitrogen, and water, the incubation taking place at a ...


6
Michael H Fisher, Richard L Tolman: Carbohydrate derivatives of milbemycin and processes therefor. Merck & Co, David L Rose, Harry E Westlake, J Jerome Behan, January 16, 1979: US04134973 (36 worldwide citation)

Carbohydrate derivatives of the antibiotic substance milbemycin, also identified as B-41, and of 13-hydroxy milbemycin are prepared. The carbohydrate groups are attached to the available hydroxy groups of milbemycin and to the hydroxy group synthesized at the 13-position. The reactions may be made s ...


7
Edward J Cragoe Jr, Otto W Woltersdorf Jr: [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids. Merck & Co, Michael C Sudol Jr, J Jerome Behan, Rudolph J Anderson, August 10, 1976: US03974212 (36 worldwide citation)

[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepar ...


8
Edward J Cragoe Jr, Otto W Woltersdorf Jr: [1-Hydroxy-5-indanyloxy (or thio)]-alkanoic acids. Merck & Co, Michael C Sudol Jr, J Jerome Behan, March 15, 1977: US04012524 (35 worldwide citation)

[1-Hydroxy-5-indanyloxy (or thio)]alkanoic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and hypouricemic activity. The acid products are prepared by several synthetic methods.


9

10
William J McAleer, Maurice R Hilleman: Syringe containing frozen vaccine. Merck & Co, Donald J Perrella, J Jerome Behan, April 19, 1977: US04018222 (33 worldwide citation)

Vaccine delivery system wherein an aqueous vaccine diluted to human dosage concentration is loaded into presterilized single dosage syringes having a squeezable body portion and wherein a plurality of these syringes are sealed inside a bag and the contents of the syringes are frozen to preserve the ...